炎症重编程调节了与多克索鲁比相关心肌病症的比格尔犬三维应变能力和心脏功能的变化
Yifan Chen1, Yihui Shen2, Hui Zhang2
1Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Key Laboratory of Viral Heart Diseases, National Health Commission, 200032 Shanghai, China.
Reviews in cardiovascular medicine
|July 30, 2024
概括
beagle 狗的 doxorubicin (DOX) 心脏毒性与炎症重编程有关,主要影响右心功能和应变能力. 这种新模型揭示了早期的心脏损伤及其与炎症的相关性.
科学领域:
- 心脏病学 心脏病学
- 在瘤学瘤学.
- 毒理学 毒理学 毒理学
背景情况:
- 多克索鲁比 (DOX) 化疗导致心脏毒性,限制了其临床使用.
- 制定有效的心脏保护策略来预防DOX诱导的心脏毒性至关重要.
- 建立了一个新的比格尔犬模型来研究DOX诱导的心脏功能障碍,并探索炎症重编程的作用.
研究的目的:
- 建立一个低死亡率的犬类模型,用于多克索鲁比诱导的心脏功能障碍.
- 调查炎症重编程与多克索鲁比相关心脏毒性之间的关系.
- 在狗模型中评估早期心脏损伤和功能变化.
主要方法:
- 20只雄性比格尔犬被分为多克索鲁比辛 (DOX) 和对照组.
- DOX被累计给予高达12mg/kg,并评估了血清生物标志物和心肌病理.
- 实时定量PCR,心声和功能丰富分析进行.
主要成果:
- DOX治疗显著增加了心脏生物标志物 (hs-cTnT,NT-proBNP) 并诱导心肌退化.
- 观察到炎症基因转录,原体代谢基因和天然尿素家族基因的升高.
- 显著的右心室应变和喷射率下降比左心室变化更早发生,与炎症重编程有很强的相关性.
结论:
- 炎症重编程显著调解心脏功能障碍和右心脏应变能力障碍.
- 已建立的比格尔犬模型有效地证明了与多克索鲁比辛相关的心肌病变.
- 研究结果强调了炎症在多克索鲁比诱导的心脏毒性中扮演着重要的角色,特别是在右心室.
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