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Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
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Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
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相关实验视频

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肠道微生物组和动脉样硬化:孟德尔的随机化研究

Yue Li1, Yunxian Chen1, Zhe Li2

  • 1Department of Cardiology, Yue Bei People's Hospital, Shantou University Medical College, 512099 Shaoguan, Guangdong, China.

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肠道细菌Firmicutes与降低冠状动脉样硬化风险有因果关系. 这一发现可能通过专注于肠道微生物群干预来为动脉样硬化提供新的治疗点.

关键词:
大脑动脉样硬化冠状动脉样硬化 - 冠状动脉样硬化我们的肠道微生物群.科目 坚固的植物科

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科学领域:

  • 遗传学 是一个遗传学.
  • 微生物学 微生物学
  • 心血管疾病 心血管疾病

背景情况:

  • 动脉样硬化越来越多地与肠道微生物群有关,但因果关系和特定种群仍然不清楚.
  • 现有的研究表明肠道微生物群组成的变化,阻碍了最终的结论.
  • 识别关键的肠道微生物群种群 (GM种群) 对于了解它们在动脉样硬化中的作用至关重要.

研究的目的:

  • 识别与动脉样硬化相关的各种分类层次 (从族群到属) 的特定肠道微生物群.
  • 用先进的统计方法调查肠道微生物群和动脉样硬化之间的潜在因果关系.

主要方法:

  • 通过使用MiBioGen联盟 (肠道微生物群) 和FinnGen联盟 (动脉样) 的总结数据,进行了两样本的门德尔随机化 (MR) 分析.
  • 主要分析方法是逆方差加权 (IVW) 方法,辅以加权中位数,MR-Egger和其他MR技术.
  • 灵敏度分析包括Cochrane的Q测试,MR-Egger拦截,MR-PRESSO和留出一个漏洞的分析,以确保稳定性.

主要成果:

  • 该MR研究分析了211种肠道微生物群,以确定它们与动脉样硬化的风险关联.
  • 确定了20个名义上的联系和一个显著的因果关系.
  • 菲尔姆Firmicutes表现出与降低冠状动脉样硬化 (OR = 0.852,p = 0.004) 的显著因果关系,在邦费罗尼校正后持续存在.

结论:

  • 类Firmicutes因果关系地影响了冠状动脉样硬化发病率的减少.
  • 这些发现表明,向肠道微生物群,特别是Firmicutes,可能代表动脉样硬化的一种新治疗策略.