Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

8.5K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
8.5K
Types of RNA01:20

Types of RNA

5.7K
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
5.7K
Formation of Muscle Fibers from Myoblasts01:13

Formation of Muscle Fibers from Myoblasts

4.8K
De novo myogenesis, or the formation of muscle fibers, begins during the early embryonic stages. The skeletal muscle is formed from somites– blocks of embryonic cell layers. The somites are further divided into dermatomes, myotomes, sclerotomes, and syndetomes. Among these, the myotomes give rise to muscle fibers.
Muscle progenitor cells (MPCs) are formed from the myotomes. MPCs express genes that encode the transcription factors Pax3 and Pax7. Along with Pax 3/7, other transcription...
4.8K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

High-throughput ligand discovery in living cells using the cellular protein stability enhancement assay.

Acta pharmaceutica Sinica. B·2026
Same author

Cost-Effectiveness of Universal Low-Dose Computed Tomographic Lung Cancer Screening in Singapore.

JAMA network open·2026
Same author

Sympathetic nervous system-mediated fibro-adipogenic progenitor mobilization drives stroke-related sarcopenia.

Cell discovery·2026
Same author

Single-atom catalysts enabled by natural leaf vein networks for catalytic ozonation of wastewater.

Bioresource technology·2026
Same author

Analysis of the boundary load impact on porcelain insulators and DIC test.

Scientific reports·2026
Same author

Multimodal imaging and quantification of lanthanide chelate-labeled micro- and nanoplastics in plants.

Nature protocols·2026

相关实验视频

Updated: Jun 18, 2025

Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix
10:21

Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix

Published on: June 14, 2016

10.0K

非编码RNA和心脏纤维化

Changyong Wu1, Suli Bao1, Ruijie Li1

  • 1Department of Cardiology, The First Affiliated Hospital of Kunming Medical University, 650000 Kunming, Yunnan, China.

Reviews in cardiovascular medicine
|July 30, 2024
PubMed
概括

心肌纤维化是心力衰竭和心律失常的关键因素,缺乏有效的治疗方法. 非编码RNA正在成为关键的调节器和这种疾病的潜在治疗点.

科学领域:

  • 心血管生物学 心血管生物学
  • 分子医学是分子医学.
  • 在RNA生物学,RNA生物学.

背景情况:

  • 心肌纤维化是晚期心血管疾病的标志,有助于心力衰竭和心律失常.
  • 目前的心肌纤维化治疗方法有限,因为对其分子基础的理解不充分.
  • 非编码RNA在心脏细胞过程和疾病发展中起着关键作用.

研究的目的:

  • 审查非编码RNA与心肌纤维化发展之间的复杂关系.
  • 突出非编码RNA在心脏纤维细胞增殖和转化中的调节作用.
  • 探索非编码RNA作为生物标记物和心脏纤维化治疗点的潜力.

主要方法:

  • 对调查心血管疾病中非编码RNA的研究进行文献综述.
  • 分析关于非编码RNA调节心脏纤维细胞行为的研究.
  • 综合当前关于非编码RNA作为治疗点的知识.

主要成果:

  • 非编码RNA在心肌细胞分化,转录和亡中起重要作用.
  • 非编码RNAs通过特定的信号通路调节心脏纤维细胞的增殖和激活.
  • 有证据表明,非编码RNA可以作为心脏纤维化预测生物标志物.
关键词:
生物标志物生物标志物基因调节 基因调节 基因调节分子机制的分子机制.心肌纤维化是心肌纤维化的一种.没有编码的RNAs.

更多相关视频

In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge
09:53

In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge

Published on: June 15, 2018

7.3K
Suppression of Pro-fibrotic Signaling Potentiates Factor-mediated Reprogramming of Mouse Embryonic Fibroblasts into Induced Cardiomyocytes
09:16

Suppression of Pro-fibrotic Signaling Potentiates Factor-mediated Reprogramming of Mouse Embryonic Fibroblasts into Induced Cardiomyocytes

Published on: June 3, 2018

7.3K

相关实验视频

Last Updated: Jun 18, 2025

Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix
10:21

Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix

Published on: June 14, 2016

10.0K
In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge
09:53

In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge

Published on: June 15, 2018

7.3K
Suppression of Pro-fibrotic Signaling Potentiates Factor-mediated Reprogramming of Mouse Embryonic Fibroblasts into Induced Cardiomyocytes
09:16

Suppression of Pro-fibrotic Signaling Potentiates Factor-mediated Reprogramming of Mouse Embryonic Fibroblasts into Induced Cardiomyocytes

Published on: June 3, 2018

7.3K

结论:

  • 非编码RNA是心肌纤维化病原发生的关键调节者.
  • 向非编码RNA为针对心肌纤维化的新型治疗策略提供了一个有希望的途径.
  • 对非编码RNA机制的进一步研究对于开发有效的纤维化逆转药物至关重要.