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左心室末端透析直径与冠状动脉疾病患者的长期死亡率之间的关联
Qiang Li1,2, Haozhang Huang1,2, Xiaozhao Lu1,2
1Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, 510080 Guangzhou, Guangdong, China.
Reviews in cardiovascular medicine
|July 30, 2024
概括
扩大左心室终端透析直径 (LVEDD) 是冠状动脉疾病 (CAD) 患者全因死亡率的独立预测因子. LVEDD测量有助于风险分层和确定CAD管理的治疗目标.
科学领域:
- 心脏病学 心脏病学
- 心声回声扫描 (Echocardiography) 是一种心声回声扫描.
- 致病率和死亡率研究 致病率和死亡率研究
背景情况:
- 左心室末端透气直径 (LVEDD) 是一个标准的心声回声测量仪.
- 增加的LVEDD通常与左心室 (LV) 功能障碍相关.
- 在冠状动脉疾病 (CAD) 患者中,LVEDD对所有原因死亡率的预后价值仍然不清楚.
研究的目的:
- 在一大群患有CAD的患者中调查LVEDD和全因死亡率之间的关联.
- 确定LVEDD是否可以作为该人群中死亡率的独立预测指标.
主要方法:
- 从心脏病改善研究 (NCT04407936) 中对33,147名CAD患者的回顾性分析.
- 根据LVEDD测量,患者被分为四分之一.
- 卡普兰-梅尔分析,日志级别测试,限制立方线和考克斯比例危险模型被用来评估死亡风险.
主要成果:
- 总共有33,147名患者 (平均年龄63.0±10.6岁,24.0%女性) 进行了分析.
- 在平均5.2年的随访期间,死亡人数为4,288人.
- 在最高的LVEDD四分位数 (四分位数) 中的患者与较低的四分位数 (四分位数1-3,11.15%,p < 0.001) 相比,死亡率显著更高 (18.05%).
- 调整后的分析显示,最高LVEDD四分位数 (95%CI:1.09-1.30) 的全因死亡风险增加了1.19倍.
结论:
- 升高的LVEDD是CAD患者全因死亡率的独立预测因子.
- 在CAD管理中的风险分层中,LVEDD评估是有价值的.
- LVEDD可以指导治疗策略,以改善CAD患者的治疗结果.
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