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在患有先天性心脏缺陷的成年人中,心脏衰竭的预测因素
Kambiz Norozi1,2,3,4, Matthias J Müller2, Chuce Xing1
1Department of Pediatrics, Pediatric Cardiology, Western University, London, ON N6A 3K7, Canada.
Reviews in cardiovascular medicine
|July 30, 2024
概括
患有先天性心脏缺陷 (ACHD) 的成年人存在心力衰竭 (HF) 的高风险. 运动能力,NT-proBNP水平和QRS持续时间的组合可以预测ACHD患者的HF发展.
科学领域:
- 心脏病学 心脏病学
- 成人的先天性心脏病 (ACHD)
- 心脏衰竭 (HF) 是一种心脏衰竭.
背景情况:
- 成年人患有先天性心脏缺陷 (ACHD) 的人口正在增长,心力衰竭 (HF) 是导致过早死亡的首要原因.
- 有限的信息存在于ACHD患者中HF的预测因素,突出了关键的知识差距.
研究的目的:
- 在15年的随访期后,重新检查一组ACHD患者.
- 识别和评估HF在ACHD患者中发展的预测因素.
主要方法:
- 一项随访研究涉及249名患有已修复或缓解先天性心脏缺陷 (CHD) 的成年人,最初是在2003年进行的.
- 研究了最大氧气摄入量 (VO2max),N-终端脑前性尿素 (NT-proBNP) 和QRS复合体持续时间对HF发育的预测值.
主要成果:
- 对HF发展的显著预测因素包括NT-proBNP水平>1.7倍以上的正常上限,VO2max<预测值的73%,QRS持续时间>120毫秒.
- 这三个参数的组合显示了高预测值 (AUC = 0.75) 的HF发展.
结论:
- VO2max,NT-proBNP和QRS持续时间的组合有效地预测了15年内ACHD患者的HF发展.
- 在ACHD患者中加强对这些参数的监测可能有助于预防HF和早期干预.
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