扫描持续时间对CT输液值在移从细胞癌的转移的影响
Chaan S Ng1, Adam G Chandler2, Yanwen Chen3
1Department of Radiology, Unit 1473, University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.
较长的CT输液扫描获取时间提高了细胞癌转移中的CT输液参数的稳定性和可重现性. 为了获得可靠的结果,建议采集时间为380秒.
科学领域:
- 放射学 放射学是一门学科.
- 医疗成像医学成像
- 在瘤学瘤学.
背景情况:
- 图像扫描输液 (CTp) 参数值受到扫描采集持续时间 (tacq) 的影响.
- CTp测量的可重现性受到测量不确定性的挑战.
- 细胞癌转移 (mRCC) 对CTp分析提出了独特的挑战.
研究的目的:
- 评估获取持续时间 (tacq) 对CTp参数的影响.
- 评估CTp参数稳定性在mRCC转移的胸部和腹部位置.
- 为了确定可靠CTp测量的最佳采集时间.
主要方法:
- 在53名mRCC患者中对131个CTp评估进行了回顾性分析.
- 分布式参数建模用于导出CTp参数,包括血流 (BF),血液体积 (BV),平均传输时间 (MTT) 和透性 (PS).
- 处以惩罚的多项式回归 (SPLINE) 和等效测试,以分析参数稳定性作为tacq的函数.
主要成果:
- CTp参数值表现出变化,采集时间更短.
- 所有参数都显示了在所有位置的较长tacq的稳定性增加.
- 与BF,BV和MTT相比,肝脏参数 (HAP,HAF) 和PS的稳定性需要更长的获取时间.
- 需要380秒的获取时间才能对所有参数和器官产生适度的信心.
结论:
- 增加CT采集时间可以提高CT perfusion参数的稳定性.
- 较长的tacq直接提高CTp测量的可重现性.
- 优化tacq对于mRCC中准确的CTp评估至关重要.
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