动脉硬度和左心室透静功能在患有高甲状腺症的人群中
Lijuan Yang1, Xiuqin Sun1, Hong Tao1
1Department of Endocrinology and Metabolism, Beijing Anzhen Hospital, Capital Medical University, 100029 Beijing, China.
Reviews in cardiovascular medicine
|July 30, 2024
概括
甲状腺功能对心血管健康产生影响,即使在euthyroidism. 甲状腺刺激激素 (TSH) 在乙甲状腺范围内的较高水平与动脉硬度 (AS) 增加和左心室 (LV) 扩张功能受损相关.
科学领域:
- 心脏病学 心脏病学
- 内分泌学 在内分泌学.
- 医学诊断 医学诊断 医学诊断
背景情况:
- 亚临床甲状腺功能低下症 (SCH) 与心血管风险有关.
- 动脉硬 (AS) 和左心室 (LV) 扩张功能障碍是已知的SCH的并发症.
- 有限的研究存在于这些心血管参数在euthyroid个体.
研究的目的:
- 为了研究心脏动脉硬 (AS) 和左心室 (LV) 扩张功能障碍在euthyroid个体.
- 为了探索甲状腺功能和心血管参数在euthyroidism之间的关联.
主要方法:
- 249名脱甲状腺参与者根据TSH水平被分为两组.
- 动脉硬度使用手臂脚脉冲波速率 (baPWV) 进行评估.
- 通过彩色多普勒声心谱评估LV透气功能.
主要成果:
- 与A组相比,B组 (较高的TSH) 的baPWV显着更高,LV的透缩功能受损 (较低的E/A比率).
- 自由三甲状腺素 (FT3) 水平和静脉血压在各组之间有显著差异.
- FT3与较高的baPWV相关;E/A比率与TSH,FT3和baPWV相关.
结论:
- 甲状腺功能和AS/LV透析功能之间存在关联.
- 在euthyroid范围内提升的TSH水平可能表明早期的心血管变化.
- 需要进一步的研究来验证这些发现.
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