健康成年人中的中白素-6和心血管事件:MESA
Muhammad Shahzeb Khan1, Khawaja M Talha2, Muhammad Haisum Maqsood3
1Duke University Medical Center, Duke Clinical Research Institute, Durham, North Carolina, USA.
高水平的互白素-6 (IL-6) 与心血管疾病 (CVD) 风险和死亡率的增加有关. 这种关联在各种种族和种族群体中保持一致,强调IL-6是不利健康结果的重要生物标志物.
科学领域:
- 心血管疾病的研究研究.
- 炎症和健康结果.
- 种族和民族的健康差异.
背景情况:
- 升高的IL-6水平与患有或没有心血管疾病 (CVD) 的患者的不良结果有关.
- 了解IL-6在没有基线心血管疾病的个体中的作用,对于风险分层和预防策略至关重要.
研究的目的:
- 调查循环IL-6水平与在没有基线心血管疾病的个体中心血管疾病事件发生率之间的关联.
- 检查这些协会跨越不同的种族和种族群体.
主要方法:
- 动脉样硬化多民族研究 (MESA) 队列的观察分析.
- 在基线测量IL-6水平,并分为三个三分之一.
- 考克斯比例危险回归模型用于评估与所有原因死亡率,心血管死亡率,非心血管死亡率和心力衰竭的关联.
主要成果:
- 较高的IL-6水平 (三位数3与三位数1) 与所有原因死亡率 (HR:1.98),心血管死亡率 (HR:1.55),非心血管死亡率 (HR:2.05) 和心力衰竭 (HR:1.48) 的调整后风险增加有关.
- 作为连续变量,较高的IL-6也显示了所有个体结果的风险增加.
- IL-6水平与不良结果之间的关联在种族和种族群体之间是一致的.
结论:
- 高循环IL-6水平是不良心血管结果和所有原因死亡率增加的重要预测因素.
- 这些发现强调了IL-6在不同人群中作为生物标志物的一致作用,无论基线心血管疾病状况如何.
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