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相关概念视频

Immunodeficiency Diseases01:25

Immunodeficiency Diseases

929
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
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Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

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The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
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Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

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Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
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Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

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Overview
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Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

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Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
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Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

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Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
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Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis
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在B-淋巴缺陷的非传染性并发症中,常见的变量免疫缺陷是不传染性的.

S Pashangzadeh1, S Delavari1,2, T Moeini Shad1

  • 1Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children´s Medical Center, Tehran University of Medical Science, Tehran, Iran.

Journal of investigational allergology & clinical immunology
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概括

常见变性免疫缺陷 (CVID) 患者经常经历非传染性并发症,特别是那些患有B细胞淋巴衰竭的患者. 早期监测和治疗对于管理CVID并发症和改善患者结果至关重要.

关键词:
这是一种自身免疫力.常见的可变免疫缺陷.免疫系统的调节失调.免疫的先天错误 免疫的先天错误恶性瘤是一种恶性瘤.主要免疫缺陷是一个主要的免疫缺陷.

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科学领域:

  • 免疫学 免疫学 免疫学
  • 血液学 血液学 血液学
  • 遗传学 遗传学 是一个

背景情况:

  • 常见变性免疫缺陷 (CVID) 是一种主要免疫缺陷,其特征是显著的症状表现.
  • 非传染性并发症对CVID患者来说是一个主要的挑战,除了频繁的传染性问题.

研究的目的:

  • 调查CVID患者非传染性并发症的患病率和特征.
  • 确定B细胞淋巴缺血和CVID中特定的非传染性表现之间的关联.

主要方法:

  • 从国家数据库中对CVID患者进行回顾性队列研究.
  • 根据B细胞淋巴衰竭的存在或不存在,将患者分为不同组.
  • 评估人口统计数据,实验室结果,器官参与,自身免疫和淋巴增殖性疾病.

主要成果:

  • 在387名CVID患者中,66.4%的人被诊断出非传染性并发症.
  • 肠病,自身免疫和淋巴增殖性疾病是常见的,分别影响35.1%,24.3%和21.4%.
  • B细胞淋巴缺血与自身免疫性,特定器官 (皮肤,内分泌,肌肉骨) 参与的频率增加以及某些自身免疫性表现 (风湿学,血液学,胃肠道) 相关.

结论:

  • 非传染性并发症,特别是与B细胞淋巴缺血相关的并发症,需要定期监测患者.
  • 建议综合管理,包括除免疫球蛋白替代疗法之外的药物治疗.
  • 积极的随访旨在预防后续并提高CVID患者的生活质量.