在怀孕期间为妇女补充维生素D
Cristina Palacios1, Lia L Kostiuk2, Anna Cuthbert3
1Department of Dietetics and Nutrition, Florida International University, Miami, Florida, USA.
The Cochrane database of systematic reviews
|July 30, 2024
概括
这项审查发现,怀孕期间补充维生素D对大多数母亲和新生儿的结果具有非常不确定的影响. 虽然它可以减少严重的产后出血,但需要更多的研究来确认益处和安全性.
科学领域:
- 孕产妇和胎儿的医学
- 营养科学 营养科学
- 以证据为基础的产科.
背景情况:
- 怀孕期间补充维生素D正在探索对母亲和新生儿健康的潜在益处.
- 潜在的改善包括减少早产,低出生体重和严重的分娩后出血.
- 维生素D的安全性和有效性,单独或与其他微量营养素一起,需要进行彻底的检查.
研究的目的:
- 评估怀孕期间维生素D补充剂的安全性和有效性.
- 评估单独或与或其他维生素/矿物质结合的维生素D.
- 为了确定与安慰剂或没有干预相比,对母亲和新生儿健康结果的影响.
主要方法:
- 随机和准随机对照试验的系统审查和元分析.
- 搜索了Cochrane怀孕和分娩试验注册和其他数据库,截至2022年12月.
- 使用GRADE方法评估研究的资格,偏差风险和证据的确定性.
主要成果:
- 仅维生素D对子宫前,妊娠期糖尿病和早产产生非常不确定的影响.
- 有证据表明,可能会减少严重的产后出血 (低确定性) 和低出生体重 (不确定性).
- 结合维生素D与或其他微量营养素,对大多数结局产生了非常不确定的证据.
结论:
- 目前关于怀孕期间补充维生素D的证据在很大程度上是低或非常低的确定性.
- 虽然建议减少产后出血等一些潜在的益处,但它们基于有限的数据.
- 严格,高质量的随机试验对于澄清怀孕期间维生素D补充剂的真实效果和安全性至关重要.
更多相关视频
10:46A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
Published on: December 9, 2015
10.7K
06:47Isolation of Mesenchymal Stem Cells from Human Alveolar Periosteum and Effects of Vitamin D on Osteogenic Activity of Periosteum-derived Cells
Published on: May 4, 2018
9.3K
相关概念视频
01:23Role of Skin in Vitamin D Synthesis
5.1K
The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
5.1K
01:25Role of Vitamins in Maintaining Bone Health
3.2K
The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
3.2K
01:07Teratogenicity
2.4K
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
2.4K
01:30Vitamins
611
Vitamins, derived from the Latin word for life, are essential organic substances required in small quantities for optimal growth and overall well-being. Unlike other organic nutrients, vitamins don't act as sources of energy or building materials but rather facilitate these nutrients' utilization by the body. Vitamins are predominantly coenzymes, assisting enzymes in specific chemical actions, like the oxidation of glucose for energy involving B vitamins. Most vitamins are not produced...
611
01:18Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants
1.2K
Oral anticoagulants are vital tools in preventing and treating blood clotting disorders. This diverse class of medications can be categorized as vitamin K antagonists, exemplified by warfarin, and direct thrombin inhibitors (DTIs), such as dabigatran, as well as factor Xa inhibitors, including rivaroxaban.
Warfarin, a prominent vitamin K antagonist family member, exerts its effect by inhibiting the enzyme VKORC1 (vitamin K epoxide reductase complex 1). By hindering this enzyme, warfarin...
Warfarin, a prominent vitamin K antagonist family member, exerts its effect by inhibiting the enzyme VKORC1 (vitamin K epoxide reductase complex 1). By hindering this enzyme, warfarin...
1.2K
01:22Diabetes Mellitus: Type 2 and Gestational
2.3K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.3K