基线体重恢复和头癌死亡风险在头癌中的死亡风险
Amanda J Bastien1, Luv Amin1, Missael Vasquez1
1Division of Otolaryngology - Head and Neck Surgery, Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Head & neck
|July 30, 2024
概括
许多头癌患者在治疗后扎着减肥和恢复. 早期的语音/语言病理学和营养咨询显著改善了生存结果.
科学领域:
- 在瘤学瘤学.
- 营养科学 营养科学
- 语音语言病理学 语言病理学
背景情况:
- 减肥和恢复是头癌 (HNC) 治疗的关键但未被充分研究的方面.
- 诸如语音/语言病理学 (SLP) 和营养咨询等可修改因素对体重的影响尚不清楚.
- 本研究研究了减肥趋势,基线体重恢复 (BWR) 和跨学科护理对HNC结果的影响.
研究的目的:
- 分析接受治疗意图辐射的HNC患者的减肥模式.
- 为了确定治疗后的基线体重恢复 (BWR) 的速度和时间.
- 评估BWR,跨学科咨询 (SLP,营养) 和瘤结果之间的关联.
主要方法:
- 在2016年1月至2022年1月期间,对266名HNC患者进行放射治疗的回顾性队列研究.
- 分析重量变化,BWR的时间和咨询数据.
- 用于评估治疗因素和生存的多变量考克斯回归模型.
主要成果:
- 平均体重减轻12.6%,辐射后3.0个月达到最低点;只有47.4%的人实现了BWR.
- 达到BWR的中位时间为10.5个月;BWR在6个月后与改善的整体存活率 (HR 0.28) 有关.
- SLP咨询 (HR 0.40) 和营养咨询 (HR 0.34) 独立地与更好的生存率有关.
结论:
- 很大一部分HNC患者没有达到基线体重恢复,影响生存率.
- 早期的SLP和营养咨询是可修改的因素,可以独立改善瘤结果.
- 促进BWR和多学科护理的干预措施对于降低HNC患者的死亡率至关重要.
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