从实验设计的尼古丁盐基电子液体中制造的气溶的物理和化学特性
1Office of Science, Center for Tobacco Products, U.S. Food and Drug Administration, Silver Spring, Maryland 20993, United States.
Chemical research in toxicology
|July 30, 2024
概括
在电子尼古丁输送系统 (ENDS) 中常见的尼古丁盐电子液体,与自由基尼古丁相比,产生不同的有害化学特征和尼古丁输送效率. 尼古丁盐中使用的酸类型显著影响气溶成分和尼古丁产量.
科学领域:
- 化学 化学 化学
- 毒理学 毒理学 毒理学
- 材料科学 是一种材料科学.
背景情况:
- 尼古丁盐电子液体在美国电子尼古丁递送系统 (ENDS) 市场上占据主导地位,这是由于其高效的尼古丁递送.
- 从尼古丁盐电子液体中产生的气溶的化学和物理性能仍然不太清楚.
- 了解这些特性对于评估ENDS安全性和用户暴露至关重要.
研究的目的:
- 从实验室制造的自由基尼古丁和尼古丁盐电子液体中产生的气溶的有害和潜在有害成分 (HPHC) 和颗粒大小的特征.
- 为了研究不同碳酸 (酸,酸,乳酸,酸,酸) 对气溶性能的影响.
- 为了比较各种尼古丁盐配方和自由基尼古丁之间的尼古丁递送效率和HPHC产量.
主要方法:
- 制备实验室制造的自由基尼古丁和尼古丁盐电子液体,使用不同的碳酸.
- 在已建立的方法使用生成的气溶中分析HPHCs.
- 气溶颗粒大小的测量.
- 量化尼古丁和碳酸在气溶中的产量.
主要成果:
- 与自由基尼古丁喷雾剂相比,尼古丁盐喷雾剂表现出明显的HPHC配置文件,碳酸盐影响了结果.
- 多碳素酸 (酸,酸,酸) 导致比单碳素酸 (酸,乳酸) 更高的亚克罗林产量.
- 尼古丁酸和乳酸配方显示出最高的尼古丁含量和产量,以及最高的碳酸产量.
- 颗粒大小主要受到电子液溶剂比率 (PG:VG) 的影响,而不是尼古丁类型 (盐与自由基).
结论:
- 尼古丁盐电子液中的碳酸盐不是惰性的,并且显著影响气溶成分,尼古丁输送和HPHC生成.
- 酸的选择会影响阿克罗莱因和尼古丁的产量,这表明ENDS的下游效应.
- 需要进一步的研究,以充分阐明电子液体配方和气溶特性之间的复杂相互作用,以实现更安全的ENDS产品开发.
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