焦虑症患者的LSD辅助治疗:开放标签前性12个月的随访
Friederike Holze1,2, Peter Gasser3, Felix Müller4
1Clinical Pharmacology and Toxicology, Department of Biomedicine and Department of Clinical Research, University Hospital Basel and University of Basel, Switzerland.
概括
在长期内,LSD辅助疗法显著减少了焦虑和抑郁症状. 患者经历了持续的好处和积极的个性变化,突出了其作为焦虑症治疗新疗法的潜力.
科学领域:
- 精神病学是一个精神病学.
- 心理药理学 心理药理学
- 临床心理学 临床心理学
背景情况:
- 焦虑障碍是一个重大的全球健康挑战.
- 目前对焦虑的治疗选择在有效性和可访问性方面有限.
- 迫切需要新的治疗方法来解决这一公共卫生负担.
研究的目的:
- 评估 lysergic acid diethylamide (LSD) 辅助疗法的长期安全性和疗效.
- 评估LSD辅助治疗对患者焦虑症状的持续影响.
- 研究LSD辅助治疗对伴随性抑郁症和人格特征的影响.
主要方法:
- 一个双盲,安慰剂控制,交叉试验的长期随访,涉及39名参与者.
- 参与者在两个会议中接受了口服LSD (200μg) 或安慰剂.
- 焦虑,抑郁和人格特征的评估发生在治疗后1年,使用验证的问卷 (STAI-G,BDI,NEO-FFI).
主要成果:
- 在LSD治疗组中,与基线相比,观察到焦虑症状 (STAI-G得分) 持续减少.
- 在并发性抑郁症症状 (BDI分数) 中报告了显著的改善.
- 在人格特征中观察到神经病症的显著减少和外向的增加.
结论:
- 用LSD辅助治疗证明了在减少焦虑症状方面持续的长期疗效.
- 该疗法还对伴随性抑郁症和人格特征产生积极影响.
- 患者认为迷幻体验带来了积极和持久的好处,这表明了有前途的治疗途径.
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