预防绵羊冠状动脉,用于血管移植手术和计算机断层扫描血管造影
Ziyu Wang1,2, Hugh Paterson3, Lisa Partel4
1School of Life and Environmental Sciences, Faculty of Science, the University of Sydney, Sydney, Australia.
Tissue engineering. Part C, Methods
|July 30, 2024
概括
在血管移植手术期间,可以减少羊动脉 (CA) . 局部血管扩张剂,帕帕维林化和维拉帕米尔,有效地预防了,改善了这种动物模型中的移植评估.
科学领域:
- 生物医学工程 生物医学工程
- 手术研究的研究.
- 血管外科 血管外科
背景情况:
- 小直径的血管移植需要大型动物模型进行临床前测试.
- 羊动脉 (CA) 是一个常见的模型,但容易发生,使移植评估复杂化.
- 缺乏有效的血管扩张方案来缓解羊的CA.
研究的目的:
- 评估在血管移植手术期间减少羊动脉 (CA) 的方法.
- 为了比较CT血管学接入路径对CA的影响.
- 评估特定血管扩张剂在预防手术内CA的疗效.
主要方法:
- 四只羊接受了CT血管造影和动脉 (CA) 移植手术.
- CT血管造影是通过无名动脉 (CA通道) 或上升性大动脉 (大腿动脉通道) 进行的.
- 血管扩展剂 (帕帕维林,酸,维拉帕米尔) 在手术期间进行了测试;在操纵之前,帕帕维林和维拉帕米尔被局部施用.
主要成果:
- 用于CT血管造影的无名动脉接入诱导了手术前的CA和流量减少.
- 通过大腿动脉进入上升的大动脉门不会引起,并保持动脉流动.
- 局部的动脉内帕帕维林化物和维拉帕米尔预防了外科创伤诱导的CA.
结论:
- 在羊的CT血管造影中,上升性大动脉门是最好的,以避免手术前的CA.
- 局部使用帕帕维林化和维拉帕米尔有效地预防手术内绵羊CA.
- 这种优化的协议可以提高在绵羊模型中血管移植性能评估的可靠性.
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