阿什瓦甘达 (Withania somnifera) 根提取物对健康老年犬与衰老相关的变化的影响:一项随机,双盲,安慰剂控制的随机研究
Kala Kumar Bharani1, Ashok Kumar Devarasetti2, Latha Carey3
1Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science (CVSc), PVNRTVU, Hyderabad, Telangana, India.
Veterinary medicine and science
|July 30, 2024
概括
阿什瓦甘达根提取物 (ARE) 通过提高血液计数,肝脏和脏功能以及抗氧化剂水平,改善了老年狗的健康. 这种适应性草也减少了老化犬的压力和炎症.
科学领域:
- 兽医医学 兽医医学 兽医医学
- 药理学 药理学是指药理学的学科.
- 老年学是一门学科.
背景情况:
- 狗的衰老导致生理衰退和增加疾病易感性.
- 维他尼亚·索尼费拉 (阿什瓦甘达) 根提取物 (ARE) 具有免疫调节和适应性特性.
- 调查ARE在老年犬中减轻与年龄有关的变化的潜力至关重要.
研究的目的:
- 为了评估阿什瓦甘达根提取物 (ARE) 在健康老年犬的临床疗效.
- 评估ARE对老年狗的生理,免疫和压力相关参数的影响.
- 确定ARE是否可以抵消与年龄相关的衰退,并改善老年狗的整体健康状况.
主要方法:
- 一项为期60天的随机,双盲,安慰剂对照试验,涉及20只健康的老年犬 (≥8岁).
- 狗口服接受了ARE (15 mg/kg/天) 或安慰剂.
- 评估血清皮质醇,血液学,生物化学,氧化应激标志物和炎症性细胞因子.
主要成果:
- ARE显著增加了红细胞计数和血红蛋白,同时减少了白细胞计数.
- ARE改善了肝脏和功能标志物,降低了血清皮质醇水平.
- ARE显示出强大的抗氧化作用,并显著调节关键炎症标志物.
结论:
- 阿什瓦甘达根提取物 (ARE) 在老年犬中表现出适应性特性.
- ARE有效地改善了老化犬的血液和生化特征.
- ARE增强了抗氧化剂防御,降低了压力,并调节了老犬的炎症反应.
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