吃十字花蔬菜可以降低胰腺癌的风险:一篇更新的系统性审查与元分析
Genyuan Zhang1,2, Yunjia Li2, Yan Sun3
1Department of Gastroenterology, Shengjing Hospital of China Medical University, Shenyang, Liaoning Province, 110022, China.
European journal of nutrition
|July 30, 2024
概括
消费十字花类蔬菜可能会降低胰腺癌的风险. 这项对16项研究的元分析发现了显著的反向关联,支持将它们纳入饮食预防策略.
科学领域:
- 在瘤学瘤学.
- 营养流行病学 营养流行病学
- 公共卫生 公共卫生
背景情况:
- 胰腺癌是一个显著且日益增长的全球健康挑战.
- 关于十字花蔬菜消费和胰腺癌风险的流行病学研究产生了不一致的结果.
研究的目的:
- 系统地审查和对现有的流行病学证据进行元分析,以了解十字花蔬菜摄入量与胰腺癌发病率之间的关联.
- 为了澄清饮食中的十字花蔬菜与胰腺癌风险之间的关系.
主要方法:
- 在PubMed,Cochrane和Embase数据库进行系统的文献搜索,截至2023年2月.
- 包括考察十字蔬菜消费和胰腺癌的队列和病例控制研究.
- 使用随机效应模型的元分析与统计分析在 Stata 17 中进行.
主要成果:
- 16项涉及1,135,281名参与者的研究 (1989-2021) 符合纳入标准.
- 在十字花蔬菜消费和胰腺癌风险之间发现了统计学上显著的反向关联 (RR 0.83,95% CI 0.72-0.96).
- 敏感性和子组分析证实了各种因素的调查结果的稳定性.
结论:
- 这些发现支持了十字花蔬菜在旨在预防胰腺癌的饮食中的作用.
- 纳入十字花蔬菜提供了一个具有成本效益和可访问的公共卫生策略,用于预防癌症.
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