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Updated: May 10, 2026

In vitro Reconstitution of the Active T. castaneum Telomerase
09:25

In vitro Reconstitution of the Active T. castaneum Telomerase

Published on: July 14, 2011

在Tetrahymena提取物中识别特定的端粒终端转移酶活性

C W Greider, E H Blackburn

    Cell
    |December 1, 1985
    PubMed
    概括

    研究人员在Tetrahymena提取物中发现了一种新型酶,该酶可以将端粒重复 (TTGGGG) 添加到DNA原料中. 这种端粒末端转移酶活性对于真核生物中染色体末端的复制至关重要.

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    相关概念视频

    Telomeres and Telomerase02:41

    Telomeres and Telomerase

    In eukaryotic DNA replication, a single-stranded DNA fragment remains at the end of a chromosome after the removal of the final primer. This section of DNA cannot be replicated in the same manner as the rest of the strand because there is no 3’ end to which the newly synthesized DNA can attach. This non-replicated fragment results in gradual loss of the chromosomal DNA during each cell duplication. Additionally, it can induce a DNA damage response by enzymes that recognize single-stranded DNA.