导致蒸汽设备中基因形成的条件和对公共卫生的影响
Ping Wang1, Peyton Jacob2, Zhong-Min Wang1
1Environmental Health Laboratory, Center for Laboratory Science, California Department of Public Health, Richmond, California 94804, United States.
电子烟产品中的维生素E酸 (VEA) 在加热时可以产生有毒的酸气体,导致肺损伤. 这项研究证实了蒸汽过程中烯的形成,与温度和设备功率有关.
科学领域:
- 环境化学环境化学
- 毒理学 毒理学 毒理学
- 分析化学 分析化学
背景情况:
- 2019年电子烟或电子烟使用相关的肺损伤 (EVALI) 爆发导致数千人住院和死亡.
- 非法四大麻 (THC) 产品中的添加剂维生素E酸盐 (VEA) 严重涉及EVALI.
- 一个可疑的机制涉及凯,一种有毒气体,是由蒸汽过程中VEA热分解产生的.
研究的目的:
- 在现实的条件下开发和应用一种新方法来检测从VEA蒸汽中产生的 ketene.
- 为了研究蒸汽参数 (温度,设备功率) 和形成之间的关系.
主要方法:
- 使用一种新的方法来评估在可控温度 (200-500°C) 的现实设备中从VEA蒸汽中产生的基产量.
- 产生的气溶中的烯被捕获使用两个化学剂.
- 使用气体染色学-质谱学 (GC-MS) 和液体染色学与双重质谱学 (LC-MS/MS) 进行了分析,LC-MS/MS对大型样品批次的适用性更高.
主要成果:
- 这项研究证实,当VEA被蒸汽时,基的形成.
- 凯的产量随着重复的吸气而增加,并且与蒸汽温度相关.
- 设备电池功率显著影响了加热温度和随后的烯形成. 杜罗也被确定为VEA的热降解产物.
结论:
- 蒸汽维生素E酸盐 (VEA) 会产生有毒的基气体,为EVALI提供了一个可信的机制.
- 凯的形成取决于蒸汽温度和设备功率.
- 在VEA中,乙酸组对于基生成至关重要,因为单独使用维生素E时没有检测到基.
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