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Updated: Jul 16, 2026

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Use of Rabbit Eyes in Pharmacokinetic Studies of Intraocular Drugs
Published on: July 23, 2016
由VRSI研究小组对印度患者的布罗卢齐祖马布相关眼内炎
Manisha Agarwal1, Alankrita Muralidhar2, Mahesh P Shanmugam3
1Department of Vitreo Retina and Uvea, Dr Shroff's Charity Eye Hospital, New Delhi, India.
Indian journal of ophthalmology
|July 30, 2024
概括
这项研究发现,在印度患者中,brolucizumab (Pagenax) 治疗眼内炎症 (IOI) 的发生率很低. 大多数病例是轻度至中度的,视力敏度恢复,这表明了有利的安全性.
科学领域:
- 眼科医生 眼科 眼科
- 视网膜疾病 视网膜疾病
- 药物监督 药物监督 药物监督
背景情况:
- 布罗卢齐祖马布 (Pagenax) 为视网膜疾病提供了具有成本效益的治疗方法,但存在关于眼内炎症 (IOI) 的担忧.
- 关于印度IOI发生率的真实数据有限.
- 这项研究解决了对局部安全数据的需求.
研究的目的:
- 为了确定IOI的真实发病率,印度患者接受了静脉内勃鲁西祖马布治疗.
- 分析IOI事件的特征和结果.
- 为印度提供布罗卢齐祖马布使用的关键安全数据.
主要方法:
- 在21个印度三级眼科护理中心进行了回顾性,多中心,基于调查的研究.
- 自2020年10月以来,通过谷歌表格收集了关于患者人口统计,适应症,布罗卢齐祖马布治疗和IOI事件的数据.
- 统计分析包括平均值,中位数,频率和标准偏差,以评估IOI发生率和特征.
主要成果:
- 对IOI的总发病率为0.79% (在2655只眼睛中发生了21个事件),与brolucizumab.
- 大多数IOI发生在第一次注射后 (57%),平均发病时间为14天.
- IOI的严重程度从轻度 (28.5%) 到严重 (38%),其中86%的受影响眼睛恢复或改善视力敏度.
结论:
- 与之前的报告相比,印度患者的IOI发病率较低 (0.79%).
- 大多数IOI事件是轻度至中度的,视觉结果通常是有利的.
- 建议进行进一步的前性研究以验证这些发现,特别是在推剂量 (PRN) 中.
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