肥胖与多囊卵巢综合征之间的关联:对观察数据的流行病学研究
Mina Amiri1, Sana Hatoum1, Dawnkimberly Hopkins2
1Foundation for Research and Education Excellence, Vestavia, AL 35243, USA.
The Journal of clinical endocrinology and metabolism
|July 30, 2024
概括
多囊卵巢综合征 (PCOS) 患病率与全球肥胖率有轻微联系. 高质量的研究表明,肥胖和PCOS之间的联系越来越明显,这凸显了在这个领域需要严格的研究.
科学领域:
- 内分泌学 在内分泌学.
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 多囊卵巢综合征 (PCOS) 是一种普遍存在的内分泌疾病,影响女性的心脏代谢和生殖健康.
- 全球不断升级的肥胖流行病对PCOS患病率的影响尚不清楚.
研究的目的:
- 调查全球肥胖率与PCOS流行率之间的关联.
- 通过不同的PCOS诊断标准和研究方法来分析这种关联.
主要方法:
- 一个系统的审查58个人口研究 (85,956名成年人,24个国家) 发表到2023年7月.
- 使用线性回归和随机效应模型来评估平均BMI/肥胖患病率和PCOS患病率之间的联系.
- 小组分析考虑了招聘方法和研究质量,使用NIH,鹿特丹和AE-PCOS标准评估PCOS.
主要成果:
- 使用AE-PCOS标准,总体上发现了PCOS和肥胖之间的边界关联,但不是NIH或鹿特丹.
- 采用更好的招聘方法的研究显示,鹿特丹和AE-PCOS标准具有显著的积极关联.
- 高质量的研究显示了所有三个标准 (NIH,鹿特丹,AE-PCOS) 的显著关联.
- 肥胖患病率的1%上升与PCOS患病率的0.4%上升相关 (罗德丹标准).
结论:
- 在PCOS和肥胖患病率之间存在温和的关联,尽管无法确定因果关系.
- 这些发现强调了高质量的研究对于准确的PCOS流行病学至关重要.
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