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相关概念视频

Disorders of Hemostasis01:24

Disorders of Hemostasis

781
Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
781
Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

659
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
659
Extrinsic and Intrinsic Pathways of Hemostasis01:20

Extrinsic and Intrinsic Pathways of Hemostasis

6.8K
Blood clotting or coagulation involves extrinsic and intrinsic pathways, which ultimately merge into the common pathway, forming a fibrin clot.
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which...
6.8K
Clot Retraction and Fibrinolysis01:16

Clot Retraction and Fibrinolysis

5.2K
After a fibrin clot is formed, the next step is clot retraction, a vital process facilitated by platelet contractile proteins, such as actin and myosin. These proteins pull the fibrin strands closer together and condense the clot. This action reduces the size of the clot, creating a smaller, denser structure that effectively seals off the damaged vessel. Clot retraction consolidates the clot and helps with wound healing by bringing the edges of the damaged blood vessel closer together.
5.2K

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相关实验视频

Updated: Jun 18, 2025

A Fibrin-Enriched and tPA-Sensitive Photothrombotic Stroke Model
09:42

A Fibrin-Enriched and tPA-Sensitive Photothrombotic Stroke Model

Published on: June 4, 2021

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血红蛋白缺乏与反复发生的脑下内出血.

Eros Qama1, Kritika Krishnamurthy1, Joseph J Mulvey1

  • 1Department of Pathology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY, US.

Laboratory medicine
|July 30, 2024
PubMed
概括

一种罕见的出血障碍 - - 血红蛋白缺乏症,与67岁女性的复发性脑下瘤出血和视力丧失有关. 综合性凝血检测对于诊断眼部出血的原因至关重要.

关键词:
这是一个R500QQ.这就是因子II的原因.眼部出血 眼部出血原血栓波多黎各 I 组蛋白质组胺缺乏症 蛋白质组胺缺乏症上腺出血 上腺出血 上腺出血

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Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation
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Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay
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Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay

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相关实验视频

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Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation
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Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay
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科学领域:

  • 眼科医生 眼科 眼科
  • 血液学 血液学 血液学
  • 遗传学 是一个遗传学.

背景情况:

  • 眼部出血在血友病A中是已知的,但不是前列血缺乏症.
  • 亚视网膜出血可以导致突然的视力丧失.

研究的目的:

  • 报告患有前体血缺乏症的患者患上上腺下血的病例.
  • 突出凝血在眼部出血中的重要性.

主要方法:

  • 一个67岁的女人突然失明的案例报告.
  • 实验室检测证实了前列血红素缺乏 (因子II缺乏).
  • 分子研究发现了一种同卵性误解突变 (G1499A/Arg500Gln).

主要成果:

  • 患者经历了复发的脑下膜出血,包括之前的眼睛核切除.
  • 证实了前素缺乏,导致眼睛经常出血.
  • 一个新的同卵性突变R457Q被确定.

结论:

  • 血红蛋白缺乏会导致并加剧眼部出血,特别是下膜出血.
  • 包括因子II活性在内的全面凝血查对于无法解释的眼部出血患者至关重要.
  • 对于孤立的前列血水平缺陷,建议进行基因检测.