长期使用大麻与成年人皮层下拓结构连接的重组有关
R P Bell1, J R Cohen2, S L Towe1
1Department of Translational Neuroscience, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Drug and alcohol dependence
|July 30, 2024
概括
成年人慢性使用大麻与白质组织的改变有关,特别是在右皮下模块内. 这项研究使用了基于模块的连接学方法来研究这些大脑网络差异.
科学领域:
- 神经科学是一个神经科学.
- 在Connectomics上,我们提供了连接.
- 神经成像是一种神经成像.
背景情况:
- 大麻的使用在美国很普遍.
- 长期使用大麻可能会改变白质 (WM) 的完整性.
- 以前对大麻使用者的WM研究产生了不一致的结果.
研究的目的:
- 用基于模块的方法研究白质 (WM) 连接性.
- 为了澄清大麻使用是否与WM组织的差异有关.
- 为了比较常规大麻使用者和非使用者之间的组织联系.
主要方法:
- 利用连接学来绘制大脑网络的地图.
- 使用基于WM结构连接的模块分析.
- 在经常使用大麻的成年人中比较网络组织 (n=53) 与对照组 (n=60).
主要成果:
- 在多次比较纠正后,没有发现有意义的全脑差异.
- 与对照组相比,成年大麻使用者在右下皮层模块中表现出更高的模块内度,局部效率和网络强度.
- 分析的重点是大脑连接体内的10个已识别的模块.
结论:
- 成年人使用大麻与皮下WM网络组织的改变有关.
- 观察到的WM组织差异可能涉及内分泌系统在WM生长中的作用.
- 基于模块的方法提供了对大麻相关神经生物学变化的洞察.
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