杆菌感染与结直肠多/腺瘤的关联:一个单中心横截面研究
Lan Chen1, Rongrong Cao2, Jie Han2
1Department of Gastroenterology, General Hospital of Northern Theater Command, Shenyang, China; Postgraduate College, Jinzhou Medical University, Jinzhou, China.
Cancer epidemiology
|July 30, 2024
概括
杆菌 (H. pylori) 感染与结直肠多和腺瘤的更高患病率有关,特别是晚期和较大的. 这项研究表明,H. pylori可能会增加患结肠这些生长的风险.
科学领域:
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
- 传染性疾病 传染性疾病
背景情况:
- 在Helicobacter pylori (H. pylori) 感染和结肠直肠多/腺瘤之间存在关联是有争议的.
- 目前关于这种联系的现有证据是不确定的,需要进一步调查.
研究的目的:
- 研究H. pylori感染与结直肠多/腺瘤的存在,特征和位置之间的关系.
- 确定H. pylori感染是否是结肠直肠多/腺瘤的独立风险因素.
主要方法:
- 对508名接受了结肠镜检查和H.pylori检测的参与者的回顾性分析.
- 在H. pylori阳性和阴性组之间比较多/腺瘤特征 (数量,大小,位置,病理).
- 多变量逻辑回归分析,根据各种临床和代谢因素进行调整.
主要成果:
- 阳性H. pylori个体显示结直肠多/腺瘤的发病率较高,包括低度和高级腺瘤.
- 在H. pylori感染和较大的息肉 (≥6毫米和≥10毫米) 和右侧结肠息肉之间发现了显著的关联.
- 多变量分析证实,H. pylori感染是低度腺瘤,晚期腺瘤,右侧多和大多 (≥10毫米) 的独立风险因素.
结论:
- 甲状腺菌感染与结直肠多/腺瘤的风险增加有关.
- 这种感染特别与低度腺瘤,晚期腺瘤,右侧结肠和大结肠直肠有关.
相关概念视频
01:28Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies
102
Peptic ulcer disease (PUD) presents with diverse symptoms depending on the location and severity of the ulcer. Clinical manifestations of peptic ulcer include dull pain and a burning sensation in the mid-epigastric region.
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
102
01:30Peptic Ulcer Disease I: Introduction
162
Peptic Ulcer Disease (PUD) is characterized by mucosal excavation in the esophagus, stomach, pylorus, or duodenum. It can manifest as acute or chronic based on the extent and duration of mucosal involvement.
An acute ulcer, marked by superficial erosion and minimal inflammation, swiftly resolves upon identifying and addressing the underlying cause. In contrast, a chronic ulcer persists, potentially eroding through the muscular wall and forming fibrous tissue.
Peptic ulcers can also be...
An acute ulcer, marked by superficial erosion and minimal inflammation, swiftly resolves upon identifying and addressing the underlying cause. In contrast, a chronic ulcer persists, potentially eroding through the muscular wall and forming fibrous tissue.
Peptic ulcers can also be...
162
01:24Pathophysiology of Peptic Ulcer Disease: Mucosal Defense Factors
362
Peptic ulcer disease, commonly called PUD, represents a multifaceted condition characterized by disruptions in the lining of the gastrointestinal (GI) tract. Central to the protection of the gastrointestinal lining is the mucosal-bicarbonate barrier. This physiological defense mechanism is a formidable shield against the corrosive effects of gastric acid and pepsin secretion in the stomach. Its role is pivotal in maintaining the structural integrity of the stomach's inner lining.
362
01:22Pathophysiology of Peptic Ulcer Disease: Injurious Factors
558
Peptic ulcers are sores on the stomach's inner lining and the upper small intestine, which are the result of disruptions in the mucosal layer that houses parietal cells which produce gastric acid, and chief cells which secrete pepsinogen.
In the antrum region, G cells secrete the gastrin hormone that binds to gastrin-cholecystokinin-B (CCK2) receptors on parietal and enterochromaffin-like (ECL) cells in the fundic glands. Simultaneously, the vagus nerve releases acetylcholine, which binds...
In the antrum region, G cells secrete the gastrin hormone that binds to gastrin-cholecystokinin-B (CCK2) receptors on parietal and enterochromaffin-like (ECL) cells in the fundic glands. Simultaneously, the vagus nerve releases acetylcholine, which binds...
558