在精神分裂症早期阶段的个体体中,thalamus的功能和结构异常
Yujue Wang1, Lijun Ouyang1, Lejia Fan2
1Department of Psychiatry, National Clinical Research Center for Mental Disorders, National Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
在早期精神分裂症和超高风险个体中,thalamic功能连接性而不是结构发生变化,将这些变化与认知缺陷联系起来. 这突出了泰拉木斯.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 医疗成像医学成像
背景情况:
- thalamic异常与精神分裂症有关,但在前阶段的发现是不一致的.
- 认知缺陷是精神分裂症的标志性特征,泰拉马斯可能发挥关键作用.
研究的目的:
- 调查第一发精神分裂症 (FES) 和超高风险 (UHR) 个体的结构和功能性乳头层变化.
- 探索FES和UHR个体的乳头异常和认知功能之间的关系.
- 澄清泰拉马斯在精神分裂症和相关认知缺陷的发展中的作用.
主要方法:
- 多模式神经成像 (灰质体积和功能连接) 用于75名FES患者,60名UHR患者和60名健康对照 (HC).
- 皮尔森相关性分析评估了乳头膜异常与认知障碍之间的关联.
主要成果:
- 在这三个组中,没有观察到体灰质体积的显著差异.
- 与HC相比,FES患者在默认模式网络,突出网络和执行控制网络内表现出 thalamocortical 功能连接 (FC) 的降低.
- 在FES患者中,UHR个体表现出类似但较少明显的FC变化,而thalamic FC与执行速度和注意力相关.
结论:
- thalamocortical FC的降低与FES和UHR个体的认知缺陷有关.
- 这些发现阐明了精神分裂症前症候群期间的功能性胸膜变化及其与认知障碍的联系.
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