功能障碍和内化障碍中的并发症和性别差异
Nathaniel S Thomas1, Nathan A Gillespie1, Kenneth S Kendler1
1Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University, Box 980126, Richmond, VA 23298-0126, USA.
General hospital psychiatry
|July 30, 2024
概括
纤维肌痛 (FM),ME/CFS和IBS与主要抑郁症 (MDD) 和泛性焦虑症 (GAD) 高度并发,在男性中观察到更强烈的关联. 多重诊断的个体比预期的更常见.
科学领域:
- 精神病学是一个精神病学.
- 类风湿病学 类风湿病学
- 胃肠病学 胃肠病学
背景情况:
- 纤维肌痛 (FM),肌痛性脑筋炎/慢性疲劳综合征 (ME/CFS) 和易怒肠综合征 (IBS) 是功能障碍 (FD).
- 重度抑郁症 (MDD) 和泛性焦虑症 (GAD) 是常见的精神疾病.
- 了解FD和ID之间的并发症对于全面的患者护理至关重要.
研究的目的:
- 为了估计FD (FM,ME/CFS,IBS) 和ID (MDD,GAD) 之间的并发症率.
- 为了研究这些并发症模式中的潜在的性别差异.
- 为了确定这些疾病的组合是否比偶然更频繁地发生.
主要方法:
- 分析了107,849名前性生命线队列研究参与者的数据.
- 使用小型国际神经精神病学面试评估当前的IDs.
- 使用已建立的诊断标准 (ACR,CDC,ROME IV) 评估当前的 FM,ME/CFS 和 IBS.
主要成果:
- 在FD和ID之间发现了高的并发症率,赔率比率从3.2到12.6.不等.
- 与女性相比,男性的并发症关联在男性中更强.
- 患有三种或更多疾病的参与者比统计学预期的更为普遍.
结论:
- FDs和IDs表现出显著的并发症,表明共享的潜在机制.
- 需要对性别差异和特定的FD-ID组合进行进一步的研究,以了解这些疾病的病因.
- 这些发现凸显了功能障碍和精神疾病之间的相互联系.
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