在低于值强度的超高频重复性TMS通过时间总和诱导超值运动反应
Hieu Nguyen1, Charlotte Qiong Li1, Samantha Hoffman1
1Magnetic Resonance Imaging and Spectroscopy Section, Neuroimaging Research Branch, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Baltimore, MD, United States of America.
Journal of neural engineering
|July 30, 2024
概括
高频跨磁刺激 (TMS) 在特定频率上训练,但不是单个脉冲,可以通过时间总和诱导运动反应. 这一发现可能会导致更专注的深度大脑刺激系统.
科学领域:
- 神经科学是一个神经科学.
- 生物医学工程 生物医学工程
背景情况:
- 超磁刺激 (TMS) 电场在脑组织中迅速减弱,限制了深层结构的焦点刺激.
- 神经元具有独特的时间常数,使得重复的TMS脉冲的时间总和成为可能.
- 实现超值神经元反应与低值TMS脉冲是一个关键的挑战.
研究的目的:
- 为了调查高频,下值TMS脉冲列车是否可以通过时间总和诱导超值神经反应.
- 探索这个时间总和效应的频率和强度依赖.
主要方法:
- 开发了一个内部的TMS系统,能够传输高达250Hz的脉冲.
- 在22只清醒的老鼠身上,使用100,166和250赫兹的TMS脉冲列车进行了实验.
- 在不同的TMS强度下 (55%和65%MSO) 评估了运动反应和运动唤起潜力 (MEP).
主要成果:
- 在55%或65%的MSO下单次TMS脉冲没有引起运动反应.
- 166Hz和250Hz的TMS脉冲列车,但不是100Hz,成功触发了运动反应和MEP.
- 结果表明,时间总和效应取决于脉冲列车的频率和强度.
结论:
- 对TMS脉冲的时间总和可以导致超值神经元激活.
- 这种效果取决于频率,更高的频率 (166-250 Hz) 更有效.
- 这些发现支持下一代焦点TMS系统的开发,使用顺序,高频线圈激活来增强大脑深层刺激.
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