在心力衰竭患者中,左心室透静功能障碍与轻微减少的喷射分数心力衰竭患者
Noah Abel1, Tobias Schupp1, Alexander Schmitt1
1Department of Cardiology, Angiology, Haemostaseology and Medical Intensive Care, University Medical Centre Mannheim, Medical Faculty Mannheim, Heidelberg University, 68167 Mannheim, Germany.
International journal of cardiology
|July 30, 2024
概括
扩张性功能障碍 (DD) 常见于心力衰竭中轻微减少喷射分数 (HFmrEF),影响72%的患者. 然而,这项研究发现DD对HFmrEF患者的长期死亡率或再住院风险没有影响.
科学领域:
- 心脏病学 心脏病学
- 内部医学 内部医学
- 心脏衰竭研究研究
背景情况:
- 有限的数据存在于透析功能障碍 (DD) 的预后意义在心力衰竭中轻微减少喷射分数 (HFmrEF).
- 了解DD的影响对于对HFmrEF患者的风险分层和管理至关重要.
研究的目的:
- 确定心力衰竭轻微减小喷射分数 (HFmrEF) 的住院患者中腹功能障碍 (DD) 的患病率.
- 调查DD对所有原因死亡率和因HF恶化而重新住院的预后影响.
主要方法:
- 从2016-2022年对1154名住院的HFmrEF患者 (LVEF 41-49%) 的回顾性分析.
- 患者根据腹功能障碍 (DD) 的存在和严重程度对患者进行了分类.
- 主要终点:在30个月内全因死亡率;次要终点:HF再入院.
主要成果:
- 腹筋功能障碍 (DD) 在72%的HFmrEF患者中普遍存在,这些患者年龄较大,并患有更多的并发症.
- DD的存在或严重程度与所有原因死亡率或HF再住院的风险增加无关.
- 在DD患者中,死亡率调整后的HR为0.815 (p=0.161),HF再入院为0.736 (p=0.238).
结论:
- 扩张性功能障碍 (DD) 在心力衰竭患者中非常普遍,心力衰竭的患者有轻微减少的射出分数 (HFmrEF).
- 尽管DD的患病率很高,但它与HFmrEF患者的死亡率或再入院的不利长期预后无关.
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