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一个实验研究药品粉末在吸入填充期间的流动行为

Omar Ismail1, Chao Zheng1, Thomas Chamberlain1

  • 1School of Chemistry and Chemical Engineering, University of Surrey, Guildford, Surrey GU2 7XH, UK.

International journal of pharmaceutics
|July 30, 2024
PubMed
概括

这项研究确定了制药模具填充中的两个不同的流动模式:基于填充-吸入速度比的缓慢和快速填充. 在插头流量下缓慢填充时,可以达到完全填充,而快速填充则会导致不完全填充.

关键词:
模具填充 模具填充 模具填充制药粉 制药粉 制药粉粉末的流量 粉末的流量吸气填充的填充方式药片制造是指使用药片制造的.

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Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
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