在随后的双胞胎怀孕中,妊娠间隔和不良周产期结果之间的关联:全国性基于人口的研究
Shaoxin Ye1, Xuqiong Huang2, Dazhi Fan1
1Foshan Institute of Fetal Medicine, Maternal & Child Health Hospital of Foshan, Foshan, Guangdong, China (Ye, Fan, Chen, Li, Rao, Zhou, Liu, Lin); Department of Obstetrics, Maternal & Child Health Hospital of Foshan, Foshan, Guangdong, China (Ye, Fan, Chen, Li, Rao, Zhou, Guo, Liu, Lin).
American journal of obstetrics & gynecology MFM
|July 30, 2024
概括
6个月以下的短跨妊娠间隔 (IPI) 和超过5年的长IPI与双胞胎怀孕的不良结果有关. 这些发现可以帮助分层对高风险双胞胎怀孕的风险.
科学领域:
- 围产期流行病学 围产期流行病学
- 生殖健康 生殖健康
- 孕产妇和胎儿的医学
背景情况:
- 关于妊娠间隔 (IPI) 和怀孕结果的现有研究主要集中在单独怀孕.
- 关于IPI对双胞胎怀孕的影响的数据有限,这突显了当前知识上的差距.
研究的目的:
- 为了研究妊娠间隔 (IPI) 与不良周产期结果之间的关联,特别是在双胞胎怀孕中.
- 在怀孕双胞胎的妇女中,识别与妊娠间隔相关的潜在风险.
主要方法:
- 基于人口的回顾性队列研究,利用美国国家卫生统计中心的数据 (2016-2020).
- 包括多胞胎妇女 (18-45岁) 与活生生的双胞胎 (怀孕26-42周) 没有先天性异常.
- 波松回归模型和受限制的立方线被用来分析IPI与早产,SGA,NICU入院,复合发病率和婴儿死亡等结果之间的关联.
主要成果:
- 与18-23个月的IPI相比,短IPI (<6个月) 和长IPI (>5年) 与早产 (<36周) 的风险增加有关,对于妊娠年龄 (SGA) 较小,新生儿综合发病率,NICU入院和婴儿死亡的风险增加.
- 剂量反应分析显示了IPI和不良结果之间的U形或J形关联.
- 根据母亲的年龄,平价和新生儿的性别组合,相关性略有变化.
结论:
- 极端的妊娠间隔 (少于6个月或超过5年) 与双胞胎怀孕的不良结果有关.
- IPI可以作为高风险双胞胎怀孕中风险分层的一个有价值的工具.
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