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脊髓扩散MRI参数规范值的年龄和性别差异

Wei-Ling Yu¹, Fu-Zhai Ma¹, Hua Huang²

¹Department of Imaging and Interventional Radiology, The Chinese University of Hong Kong Faculty of Medicine, Hong Kong.

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概括

扩散MRI显示标准值的年龄和性别差异. 健康的女性表现出与年龄相关的ADC和IVIM-Dslow下降,而男性显示数据异质性.

科学领域:

放射学放射学是一门学科.
医疗成像医学成像
生物物理学的生物物理.

背景情况:

扩散MRI参数的规范值对于准确的解释至关重要.
了解年龄和性别对这些参数的影响对于临床应用至关重要.

研究的目的:

调查大扩散MRI参数的规范性年龄和性别差异.
为了确定表面扩散系数 (ADC) 的参考值,intravoxel不连贯运动 (IVIM) 参数 (缓慢扩散系数 Dslow, perfusion 分数 PF,快速扩散系数 Dfast) 和扩散衍生容器密度 (DDVD).

主要方法:

124名健康志愿者接受了1.5TMRI,并进行多b值扩散成像.
计算了表面扩散系数 (ADC),IVIM参数 (Dslow,PF,Dfast) 和扩散衍生的容器密度 (DDVD).
进行了统计分析,以评估年龄和性别差异.

主要成果:

女性的脏ADC和IVIM-Dslow与年龄相关的下降.
男性在脏ADC和IVIM-Dslow值中表现出显著的异质性.
IVIM参数PF和Dfast在老年人中表现出与年龄相关的增加.
在任何性别中都没有观察到与年龄相关的DDVD的显著趋势.

结论:

扩散MRI参数的解释应考虑年龄和性别.
在男性脏扩散MRI数据中的显著异质性需要仔细考虑.
脏ADC和IVIM-Dslow与年龄相关的变化在女性中更为明显.

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Magnetic Resonance Imaging

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Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...