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相关概念视频

Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

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Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
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Tumor Immunotherapy01:27

Tumor Immunotherapy

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

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T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
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T Cell Types and Functions01:24

T Cell Types and Functions

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When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
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相关实验视频

Updated: Jun 18, 2025

Lymphocyte Isolation from Human Skin for Phenotypic Analysis and Ex Vivo Cell Culture
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Lymphocyte Isolation from Human Skin for Phenotypic Analysis and Ex Vivo Cell Culture

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皮肤T细胞淋巴瘤

David M Weiner1, Alain H Rook2

  • 1Department of Dermatology, Johns Hopkins University School of Medicine, 601 North Caroline Street, 8th Floor, Baltimore, MD 21287, USA.

Hematology/oncology clinics of North America
|July 30, 2024
PubMed
概括

皮肤T细胞淋巴瘤 (CTCL) 影响皮肤,并可能扩散到其他器官. 这次审查涵盖了CTCL.

科学领域:

  • 皮肤病学和血液学
  • 在瘤学瘤学.
  • 免疫病理学 免疫病理学

背景情况:

  • 皮肤T细胞淋巴瘤 (CTCL) 包含一组非霍奇金淋巴瘤,主要影响皮肤.
  • CTCL的亚型包括真菌菌菌病,塞萨里综合征,淋巴状乳病和原发性皮肤形大细胞淋巴瘤.
  • 它经常呈现为反复性的慢性皮疹,经常模仿其他皮肤和血液病状况,导致诊断延迟.

研究的目的:

  • 为皮肤T细胞淋巴瘤提供全面的介绍.
  • 专注于临床表现,诊断方法,免疫病原发生和CTCL的管理策略.

主要方法:

  • 这是一篇综述性文章,综合了关于CTCL的现有知识.
  • 信息来自相关的医学文献和临床专业知识.
  • 该审查侧重于CTCL特征的描述和分析总结.

主要成果:

  • CTCL呈现出各种不同的临床表现,通常模仿常见的皮肤病.
  • 由于其他疾病的表现和模仿变化,诊断延迟很常见.
  • 了解免疫病原发生是有效管理的关键.

结论:

关键词:
皮肤T细胞淋巴瘤淋巴瘤状腺瘤病的发生.菌根性真菌菌菌病 (Mycosis fungoides) 是一种真菌菌病.主要皮肤形大细胞淋巴瘤.塞萨里综合征是什么意思

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Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

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  • 皮肤T细胞淋巴瘤需要仔细的临床评估和诊断工作.
  • 早期和准确的诊断对于最佳的患者结果至关重要.
  • 本综述为管理CTCL的临床医生提供了基本的理解.