系统性硬化症中的效应因子和调节性B细胞不平衡:合作还是竞争?
1Department of Dermatology, Huashan Hospital, Fudan University, the 12Th Urumqi Road, Shanghai, 200040, China. liumengguo@126.com.
Clinical rheumatology
|July 30, 2024
概括
系统性硬化症涉及B细胞,调节性B细胞 (Bregs) 不足,效应性B细胞 (Beffs) 可能导致疾病. 未来的治疗可能会针对B细胞子集,以获得更好的系统性硬化症结果.
科学领域:
- 免疫学 免疫学 免疫学
- 类风湿病学 类风湿病学
- 细胞生物学 细胞生物学
背景情况:
- B细胞在全身性硬化症 (SSc) 发病过程中至关重要,主要研究的是抗体的产生.
- 除了抗体分泌外,B细胞通过抗原呈现和细胞因子释放影响免疫力.
- B细胞子集具有相反的作用:调节性B细胞 (Bregs) 抑制炎症,而效应性B细胞 (Beffs) 促进免疫反应.
研究的目的:
- 对系统性硬化症 (SSc) 中B细胞子集的文献进行审查.
- 阐明调控性B细胞 (Bregs) 和效应性B细胞 (Beffs) 在SSc病变发生中的双重作用.
- 讨论对SSc治疗策略和生物标志物发现的影响.
主要方法:
- 文献综述和对SSc.中的B细胞现有研究的综合.
- 分析布雷格斯和贝夫斯之间的功能二分法.
- 检查针对B细胞的当前和潜在治疗干预措施.
主要成果:
- 系统性硬化症的特征是缺乏或功能障碍的调节性B细胞 (Bregs).
- 效应体B细胞 (Beffs) 通过促炎性细胞因子的产生,对SSc的病原体产生作出贡献.
- 目前的B细胞向疗法可能会影响Bregs和Beffs,可能会限制疗效.
结论:
- 未来的SSc疗法可能涉及组合策略:调节Beffs和刺激Bregs.
- 监测B细胞子集可能产生新的生物标志物,用于预测SSc复发或进展.
- 了解Bregs和Beffs之间的相互作用是推动SSc治疗和管理的关键.
更多相关视频
12:36Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry
Published on: June 26, 2018
9.4K
07:39Isolation of CD4+ T-cells and Analysis of Circulating T-follicular Helper cTfh Cell Subsets from Peripheral Blood Using 6-color Flow Cytometry
Published on: January 7, 2019
12.2K
相关概念视频
T Cell Types and Functions
967
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
967
B Cell Activation and Differentiation
1.7K
The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
1.7K
Regulation of Hematopoietic Stem Cells
3.2K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
3.2K
Inflammatory Response
1.9K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
1.9K
T Cell Activation and Clonal Selection
693
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Naive T cells that have not yet encountered an antigen express two primary CD...
693
