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评估抗逆转录病毒疗法随时间推移的成本效益:一个队列和成本效益研究

Matilde Slot^1,2,3,4, Thomas Bøjer Rasmussen^3,4, Mette Nørgaard^3,4

¹Nordic Institute of Health Economics, Gammel Munkegade 1, 8000, Aarhus C, Denmark.

PharmacoEconomics - open

|July 30, 2024

概括

丹麦的高活性抗逆转录病毒疗法 (HAART) 引入,在治疗时期内证明具有成本效益. 这种对现实世界数据的分析表明,HAART改善了艾滋病毒感染者的护理,有时会导致更有效,更便宜的治疗.

科学领域:

卫生经济学卫生经济学
公共卫生公共卫生
艾滋病毒/艾滋病研究研究

背景情况:

高活性抗逆转录病毒疗法 (HAART) 的引入标志着艾滋病毒/艾滋病管理的重大转变.
了解HAART的长期经济影响和成本效益对于医疗保健政策至关重要.
丹麦为现实世界的证据提供了有价值的环境,因为它拥有强大的医疗保健注册表.

研究的目的:

估计在丹麦引入HAART的成本和成本效益.
分析三个不同治疗时期的现实数据:HAART前期,早期HAART和晚期HAART.
评估HAART对艾滋病毒感染者 (PLHIV) 的经济价值.

主要方法:

一项使用丹麦临床和行政登记册的队列研究设计.
马尔科夫建模用于健康经济评估,结合现实世界的证据.
估计每个PLHIV.HIV获得的成本,质量调整寿命年 (QALYs) 和寿命年 (LY).
确定性和概率性灵敏度分析以确保结果的稳定性.

主要成果:

每个PLHIV的终身总成本在治疗时期内增加,从91,010欧元 (前HAART) 增加到126,317欧元 (后期HAART).
早期的HAART与之前的HAART相比具有成本效益 (ICER €1378/QALY).
与早期HAART (ICER €7385/QALY) 相比,晚期HAART也具有成本效益,敏感性分析证实了这些发现.

结论:

在丹麦实施HAART是一个具有成本效益的医疗保健战略.
哈特改进了PLHIV的护理,在不同的实施期内证明了价值.
在某些情况下,HAART导致PLHIV的治疗更有效,成本更低.

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