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以穿透组织的纳米疗法准血管破坏剂治疗的瘤微环境

Valeria Sidorenko¹, Pablo Scodeller², Ain Uustare³

¹Laboratory of Precision and Nanomedicine, Institute of Biomedicine and Translational Medicine, University of Tartu, Ravila 14b, 50411, Tartu, Estonia.

Scientific reports

|July 30, 2024

概括

血管干扰剂 (VDAs) 产生瘤变化,增强纳米粒子传递. 将VDA与iRGD和纳米疗法结合起来,显著降低了小鼠的瘤负担,这表明了一种有希望的顺序治疗策略.

科学领域:

在瘤学瘤学.
纳米医学是一种纳米医学.
分子生物学分子生物学

背景情况:

血管破坏剂 (VDAs) 诱导瘤亡,但通常会导致瘤的再生.
在VDA治疗后的瘤微环境 (TME) 修改仍然不完全理解.
开发提高VDA疗法的疗效的策略对于改善癌症治疗结果至关重要.

研究的目的:

调查VDA治疗是否使瘤对二次纳米疗法的敏感性.
评估iRGD介导纳米颗粒在VDA治疗瘤中的有效性.
评估VDAs,iRGD和新型纳米医学的联合治疗效果.

主要方法:

患有腹膜癌和乳腺癌的小鼠被用VDA的康布列塔酸A-4酸盐 (CA4P) 治疗.
在VDA治疗后评估iRGD受体 (αv-整合素和NRP-1) 的升调.
装有乌托鲁比 (UTO-PS) 的纳米颗粒与iRGD同时用于CA4P治疗的小鼠.
瘤的积累,分布和整体瘤负担被量化.

主要成果:

在外围瘤组织中,CA4P治疗提高了αv-整合素和NRP-1的调节.
同时使用iRGD增加了纳米粒子积累的3倍,并改善了腹癌的分布.
组合疗法 (CA4P,iRGD,UTO-PS聚合体) 在小鼠中显著降低了瘤负担.
组合疗法显示出最小的明显毒性.

结论:

在TME中VDA诱导的分子变化可以用于增强的纳米疗法.
iRGD增强了纳米粒子向VDA治疗瘤的输送.
序列VDA和iRGD增强纳米疗法为减少某些癌症的瘤负担提供了一个有希望的策略.

关键词:

在 CA4P 中,你会得到 CA4P .腹腔周周癌症的发生.聚合物聚合体是一种聚合物聚合物.这是一种瘤透.乌托鲁比辛是一种血管干扰剂是一种干扰器.iRGDD 是一个很好的方法.

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