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Updated: Jun 18, 2025

Immunohistochemical Detection of 5-Methylcytosine and 5-Hydroxymethylcytosine in Developing and Postmitotic Mouse Retina
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在人类植入前发育过程中,父母5-基甲基的独特动态调节了早期血统的基因表达

Dan Liang1, Rui Yan2,3, Xin Long2,3

  • 1Department of Obstetrics and Gynecology, The First Affiliated Hospital of Anhui Medical University, Hefei, China. ahmuxl@sina.com.

Nature cell biology
|July 30, 2024
PubMed
概括

早期人类胚胎从卵细胞中继承5-基甲基细胞素 (5hmC),在发育过程中发生新的5hmC生成. 这种表观遗传标记对于基因激活和早期胚胎发育至关重要.

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相关概念视频

Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
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X-chromosome...
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Inheritance of Chromatin Structures03:17

Inheritance of Chromatin Structures

Epigenetics is the study of inherited changes in a cell's phenotype without changing the DNA sequences. It provides a form of memory for the differential gene expression pattern to maintain cell lineage, position-effect variegation, dosage compensation, and maintenance of chromatin structures such as telomeres and centromeres. For example, the structure and location of the centromere on chromosomes are epigenetically inherited. Its functionality is not dictated or ensured by the underlying...
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Chromatin modification alters gene expression; therefore, scientists can add histone-modifying enzymes, histone variants, and chromatin remodeling complexes to somatic cells to aid reprogramming into pluripotent stem (iPS) cells.
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In 1928, a German botanist Emil Heitz observed the moss nuclei with a DNA binding dye. He observed that while some chromatin regions decondense and spread out in the interphase nucleus, others do not. He termed them euchromatin and heterochromatin, respectively. He proposed that the heterochromatin regions reflect a functionally inactive state of the genome. It was later confirmed that heterochromatin is transcriptionally repressed, and euchromatin is transcriptionally active chromatin.
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Commitment is the  process whereby stem cells:
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