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在风险心理状态,第一发精神病和持续的精神分裂症中,概率逆转学习的明显变化
J D Griffin1, K M J Diederen2, J Haarsma3
1Department of Psychiatry, University of Cambridge, Addenbrookes Hospital, Cambridge, CB2 0QQ, UK. Juliet.griffin@psych.ox.ac.uk.
Scientific reports
|July 30, 2024
概括
患有精神病的人,包括第一发精神病 (FEP) 和耐治疗精神分裂症 (TRS),都在努力更新信仰. 这就是TRS集团.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 计算精神病学是一种计算精神病学.
背景情况:
- 精神病与改变的信念更新和预测错误处理有关.
- 之前的研究表明,胺胺的管理影响了元层次的信心和行为政策.
- 了解不同精神病阶段的信念更新对于治疗至关重要.
研究的目的:
- 为了研究预测错误驱动的信念更新,在有风险精神状态,第一发精神病 (FEP) 和耐治疗精神分裂症 (TRS) 的个体中进行预测.
- 为了比较行为和计算建模的发现与之前关于胺胺对信心和行为的影响的研究.
- 为了检查信念更新和信心调节在精神病严重程度之间如何不同.
主要方法:
- 对临床组和匹配的对照组进行了概率逆转学习任务.
- 分析了行为数据的准确性和战略转移.
- 使用计算建模来评估基于信心的响应调制,反映了之前的胺研究.
主要成果:
- 第一次精神病发作 (FEP) 患者表现出精度降低和错误后策略转移增加.
- 治疗耐药精神分裂症 (TRS) 患者的策略转移增加,但准确性保持.
- 计算分析表明,只有TRS组在基于信心的响应中复制了胺诱导的变化.
结论:
- 行为发现表明,FEP,TRS和胺效应之间在杂环境中稳定反应的共同困难.
- 计算结果暂时表明,TRS复制了胺对信心调节的影响,与FEP不同.
- 需要进一步的研究来验证由于模型性能限制的计算发现.
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