使用HistoLens调查病理中的定量组织学特征
Samuel P Border1, John E Tomaszewski2, Teruhiko Yoshida3
1Section of Quantitative Health, Division of Nephrology, Hypertension, and Renal Transplantation, Department of Medicine, University of Florida, 1600 SW Archer Rd., Gainesville, FL, 32608, USA.
Scientific reports
|July 30, 2024
概括
新的开源工具HistoLens有助于分析疾病研究的组织图像. 它有助于识别病的关键特征,如糖尿病病和艾滋病相关病.
科学领域:
- 数字病理学数字病理学
- 计算生物学是一种计算生物学.
- 医学成像分析分析 医学成像分析
背景情况:
- 组织学分析对于诊断疾病至关重要.
- 对整个幻灯片图像 (WSI) 的定量分析存在挑战.
- 描述疾病状态之间的细微组织学差异需要先进的工具.
研究的目的:
- 介绍HistoLens,一个基于MATLAB的开源图形用户界面 (GUI).
- 为了使组织学数据集的有效视觉和定量分析,特别是WSIs.
- 为了促进疾病和实验组之间的组织学差异的表征.
主要方法:
- 在GUI开发中,HistoLens使用了MATLAB AppDesigner.
- 它允许对数字注释的WSIs进行查询.
- 该工具可视化了448个手工设计的特征 (颜色,纹理,形态,分布) 在微解剖学子区域.
- 它可以在图像中映射差异检测到的图像特征.
主要成果:
- HistoLens识别了与脏球粒状细胞特征相关的特征,区分糖尿病脏病和粉状脏病与最小变化疾病.
- 该工具发现了定量质特征,使Tg26转基因小鼠 (HIV相关脏病模型) 与野生类型小鼠区别开来.
- 这些特征与小鼠模型中的进展性病表型相对应.
结论:
- HistoLens提供了一个现成的,即时使用的工具包,用于定量病理学.
- 该软件有助于发现和描述与脏疾病相关的组织学特征.
- 它有助于区分不同的病,并使用定量图像分析了解疾病进展.
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