在澳大利亚,患有癌症的儿童在人口水平上无事件的5年生存率
Danny R Youlden1,2, Peter D Baade1,2,3, Nicolas G Gottardo4,5
1Cancer Council Queensland, Brisbane, Queensland, Australia.
Pediatric blood & cancer
|July 30, 2024
概括
在儿童癌症中,无事件生存 (EFS) 对于了解超出死亡率的治疗影响至关重要. 大约23%的儿童在五年内经历了不良事件,这凸显了全面报告结果的必要性.
科学领域:
- 儿科瘤学 儿科瘤学
- 癌症流行病学 癌症流行病学
- 临床结果研究研究
背景情况:
- 无事件生存率 (EFS) 通过包括死亡率以外的不良事件来提供治疗有效性的综合衡量标准.
- 与标准的生存指标相比,EFS提供了对儿童癌症治疗结果的更深入的见解.
- 儿童癌症的EFS人口级数据仍未得到报告.
研究的目的:
- 报告澳大利亚儿童癌症的无事件生存率 (EFS).
- 分析影响EFS的因素,包括癌症类型,疾病阶段和地理偏远.
- 在这个队列中,将EFS与所有原因观察到的生存率进行比较.
主要方法:
- 分析了来自澳大利亚儿童癌症登记处的7,067名被诊断患有癌症的15岁以下儿童 (2006-2015年) 的队列.
- 计算了五年EFS,考虑了复发,疾病进展,第二次原发性癌症或死亡等事件.
- 使用多变量灵活参数模型来评估EFS的差异,分层按癌症类型,偏远程度和阶段进行分层.
主要成果:
- 23%的患者在5年内至少经历了一次不良事件.
- 转移性/晚期疾病的复发率是转移性/晚期疾病 (22%) 和局部癌症 (11%) 的两倍.
- 总体而言,5年EFS为75.0%,而观察到的生存率为85.8%. 其他质瘤患者的EFS最低 (35.4%). 对于急性髓性白血病,EFS在偏远地区明显较低.
结论:
- 人口层面的EFS报告提高了对儿童癌症超出死亡率的影响的理解.
- 调查结果强调了考虑各种不良事件对于综合性结果评估的重要性.
- 这些数据可以为改善儿童癌症管理和患者治疗结果的策略提供信息.
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