肺部手术后阿扎龙对术后慢性疼痛的疗效:一项随机的三重盲控试验
Yang Xu1, Fei Jiang2, Shengnan Shi2
1Institute of Neuroscience and Brain Disease, Department of Pain, Xiangyang Central Hospital, Hubei University of Arts and Science, Hubei, China.
BMC anesthesiology
|July 30, 2024
概括
阿扎不预防肺部手术后的慢性疼痛. 然而,它确实减少了急性疼痛和恶心/吐在早期的术后期. 手术前的疼痛和生活方式因素与长期疼痛有关.
科学领域:
- 麻醉学和疼痛管理
- 药理学 药理学是指药理学的学科.
- 外科手术的结果
背景情况:
- 5-HT3受体对抗剂可能会增强阿片类药物止痛作用.
- 阿扎松是一种5-HT3受体对抗剂.
- 手术后的慢性疼痛是肺部手术后的一个重要问题.
研究的目的:
- 为了评估阿扎塞特龙在肺部手术后预防慢性疼痛的疗效.
- 评估阿扎龙对急性术后疼痛和恶心/吐的影响.
- 为了确定肺部手术后慢性疼痛的危险因素.
主要方法:
- 一项随机的三重盲控研究,涉及250名接受肺部手术的患者.
- 患者接受了患者控制的疼痛缓解 (PCA) 与sufentanil,有或没有阿扎.
- 在多个时间点使用数值评分表 (NRS) 评估疼痛,包括术后90天和180天.
主要成果:
- 在术后90天和180天,阿扎不降低慢性疼痛的发生率.
- 阿扎在术后第一,第二和第三天显著降低了急性术后疼痛 (NRS).
- 阿扎松降低了手术后第一天和第二天手术后恶心和吐的发生率.
- 手术前的疼痛,吸烟,饮酒和开放手术被确定为慢性疼痛的危险因素.
结论:
- 阿扎在肺部手术后预防慢性疼痛方面并不有效.
- 阿扎可以缓解急性术后疼痛,并在早期康复期减少恶心/吐.
- 识别和管理手术前的疼痛和可修改的风险因素,如吸烟和饮酒,对于缓解肺部手术后的长期疼痛至关重要.
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