是跨物种的水平基因转移,负责胆囊癌发生
Monika Rajput1, Manoj Pandey2, Ruhi Dixit1
1Department of Surgical Oncology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, 221005, India.
World journal of surgical oncology
|July 31, 2024
概括
胆囊癌中的差异反感性RNAs (asRNAs) 与细菌和病毒基因组具有相似性,这表明水平基因转移 (HGT) 可能会影响疾病的发展. 这些发现突出了癌症进展中的潜在进化联系.
科学领域:
- 基因组学就是基因组学.
- 分子生物学分子生物学
- 癌症研究 癌症研究
背景情况:
- 跨物种水平基因转移 (HGT) 是物种之间遗传物质的移动.
- 新出现的证据表明,HGT可能有助于疾病的发展和进展.
研究的目的:
- 研究胆囊癌 (GBC) 中差异表达的反感性RNAs (asRNAs) 的潜在跨物种起源.
- 通过转录和基因组分析,探索GBC中asRNAs的进化联系.
主要方法:
- 来自GBC患者的转录组数据被分析为差异性asRNA表达.
- 基本本地对齐搜索工具 (BLAST) 用于跨物种基因组比较.
- 进行了功能丰富和网络分析,以了解RNA的功能.
主要成果:
- 在GBC组织中发现了17种差异表达的asRNAs.
- 15个asRNAs与细菌和病毒基因组的序列相似,其中2个 (VPS9D1-AS1和SLC2A1-AS1) 与特定的病毒和细菌具有很高的相似性.
- 这些相似之处表明进化过程中可能发生的水平基因转移事件.
结论:
- 在GBC中的差异表达asRNA与微生物和古代人类基因组共享序列相似性,表明潜在的共同进化起源.
- 这些非编码RNA被甲基化并与P53和PI3K-AKT等癌症途径联系在一起,这表明它们在瘤发育中的作用.
关键词:
反意义RNA (asRNAs) 是一种反意义RNA.跨物种的横向基因转移 (CS-HGT)胆囊癌是一种胆囊癌.基因监管网络 基因监管网络转录形状分析 (Transcriptomic Profiling) 是一种方法,可以进行转录形状分析.asRNAs的目标是mRNAs.更多相关视频
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