阴离子合聚合物合非合段用于双增强的NIR-II光和低温光热气体疗法
Kexi Liu1, Danni Hu2,3, Liuliang He2
1Department of Emergency Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
Journal of nanobiotechnology
|July 31, 2024
概括
研究人员开发了用于近红外II (NIR-II) 光热学的新型纳米粒子. 这些纳米粒子增强光,并使联合光热和气体疗法能够通过先进的成像指导改善癌症治疗.
科学领域:
- 生物医学工程 生物医学工程
- 材料科学 材料科学 材料科学
- 纳米技术纳米技术
背景情况:
- 开发用于近红外II (NIR-II) 应用的合聚合物 (CPs) 是具有挑战性的,因为难以实现高吸收和光.
- 目前对NIR-II光疗效的现有策略是有限的,阻碍了光触发癌症疗法的发展.
研究的目的:
- 设计和合成用于增强NIR-II光和光声成像指导治疗的新型光热纳米粒子 (PPN-NO NPs).
- 研究CP的双增强策略,以改善NIR-II光和光热特性.
- 用开发的纳米粒子评估用于癌症治疗的联合光热疗法 (PTT) 和氧化 (NO) 气疗法.
主要方法:
- 合成的阴离子NIR-II CP (PBC-co-PBF-NMe3) 与集成的柔性非结合细分 (C6) 和四级盐单位.
- 通过在脂质混合物 (DSPE-PEG5000/DMPC) 上联合加载CP和NO供体 (SNAP) 来制备PPN-NONP.
- 评估了NIR-II光,光声成像和治疗疗效 in vitro 和 in vivo 使用携带瘤的小鼠模型.
主要成果:
- 设计的CP显示了增强的NIR-II光和平衡的NIR-II吸收/光热性能.
- 在体内,PPN-NO NPs表现出卓越的NIR-II光和光声学成像能力.
- 低温NIR-II PTT和NO释放的组合有效地抑制了小鼠的瘤生长.
结论:
- 一个新的设计策略成功地创建了具有双增强NIR-II光和光热特性的CP.
- PPN-NO NPs显示了先进的NIR-II成像指导组合疗法的显著潜力.
- PTT和NO疗法的协同效应为有效的癌症治疗提供了一个有希望的方法.
相关概念视频
Infrared (IR) Spectroscopy: Overview
When electromagnetic radiation passes through a material, atoms or molecules transition from a lower to a higher energy state by absorbing radiation corresponding to the energy difference between the two states. The absorption of infrared (IR) radiation causes transitions between vibrational energy levels in a molecule. Therefore, IR spectroscopy is a useful analytical tool for determining the molecular structure of molecules.
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Different compounds display unique properties due to their...
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Infrared spectroscopy, also known as vibrational spectroscopy, is mainly used to determine the types of bonds and functional groups in molecules. In aldehydes and ketones, the carbonyl (C=O) bond shows an absorption around 1710 cm-1. The C=O bond vibration of an aldehyde occurs at lower frequencies than that of a ketone. In addition to the C=O absorption in an aldehyde, the aldehydic C–H bond also gives two peaks in the 2700–2800 cm-1 range. This absorption, coupled with the C=O stretching, is...
IR Frequency Region: X–H Stretching
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Comparing the stretching vibrational frequency of C≡C triple bonds with that of double and single bonds, it is evident that C≡C triple bonds exhibit a higher stretching frequency than C=C double and C–C single bonds. Similarly, the C≡N triple bond exhibits higher stretching absorption than the C=N...
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IR Frequency Region: Fingerprint Region
IR spectra are divided into two main regions: the diagnostic region and the fingerprint region. The diagnostic region of the spectrum lies above 1500 cm−1. The absorptions resulting from single-bond vibrations of the N–H, C–H, and O–H stretch at higher wavenumbers and appear on the left side of the spectrum. The stretching absorptions of the C≡C and C≡N occur between 2100–2300 cm−1. In contrast, those arising from stretching absorptions of the C=O, C=N, and C=C occur between 1600–1850 cm−1.
The...
The...


