维生素E摄入量与一般肝硬化和肥胖人口之间的关联
Bin Chen1, Li Han2, Xingxing Chen3
1Department of Ultrasound, The First People's Hospital of Xiaoshan District, Hangzhou, Zhejiang, 311200, P.R. China.
Nutrition & metabolism
|July 31, 2024
概括
较高的维生素E (VE) 摄入量与成年人脂肪肝 (肝硬化) 的减少有关. 存在值效应,在特定的每日摄入水平以上看到的好处,特别是在肥胖个体中.
科学领域:
- 营养科学 营养科学
- 肝病学 肝病学是一种肝病学.
- 公共卫生 公共卫生
背景情况:
- 非酒精性脂肪肝 (NAFLD) 是一个日益严重的健康问题.
- 维生素E (VE) 具有抗氧化特性,可能有利于肝脏健康.
- 了解饮食VE和肝肥胖症之间的关系对于预防和治疗至关重要.
研究的目的:
- 通过使用控制减弱参数 (CAP) 测量,研究维生素E (VE) 摄入量与肝肥胖症之间的相关性.
- 为了在不同的人口子集中探索这种关系,包括肥胖个体.
- 为了确定VE摄入量对肝脂肪的潜在非线性关系和值效应.
主要方法:
- 利用了来自2017-2020年国家健康和营养检查调查 (NHANES) 5757名参与者的数据.
- 通过24小时饮食回忆和使用过渡性弹性学 (CAP) 量化肝脂肪评估每日VE摄入量.
- 采用分层多变量回归和通用添加模型来分析关系和值.
主要成果:
- 较高的VE摄入量与较低的CAP水平有显著的负相关性,表明肝脏脂肪减少.
- 这种反向相关性在肥胖个体中明显更强.
- 观察到一个曲线关系,确定了值效应:低于6.58毫克/天 (一般人群) 或7.37毫克/天 (肥胖) 的VE摄入量与CAP呈正相关,而高于这些水平的摄入量显示出负相关.
结论:
- 维生素E摄入量与肝脏脂肪含量有负相关性,这表明维生素E具有保护作用,特别是在脂肪肝的肥胖个体中.
- 在一般人群和肥胖人群中确定了 VE 摄入的特定值效应.
- 结果支持将VE纳入临床营养干预和个性化饮食策略,以管理脂肪肝疾病.
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