对65岁以上的克洛扎宾处方的分析:为期5年的回顾性研究
James Barclay1, Rahul Tomar1, Tim Gale1
1Hertfordshire Partnership NHS Foundation Trust, Hatfield, UK.
BJPsych bulletin
|July 31, 2024
概括
接受克洛扎宾治疗的老年患者经历了显著的副作用,特别是便秘. 这突显了老年人群中克洛扎诱导的胃肠道低运动 (CIGH) 的潜在风险,以及需要更好的监测.
科学领域:
- 精神病学是一个精神病学.
- 老年医学 老年医学
- 临床药理学 临床药理学
背景情况:
- 克洛扎是一种必不可少的抗精神病药物,越来越多的患者在治疗期间衰老.
- 对于老年人群中克洛扎宾的安全性和副作用概况的研究有限.
- 这项研究解决了了解65岁以上患者使用克洛扎宾的差距.
研究的目的:
- 在特定的NHS信托基金中识别老年克洛扎患者.
- 为了评估这一人口群体的副作用负担.
- 检查65岁及以上患者的共同处方模式.
主要方法:
- 在5年时间内对克洛扎患者的回顾性审查.
- 专注于65岁及以上的患者.
- 对副作用和共同处方数据的分析.
主要成果:
- 69名老年克洛扎患者被确定.
- 大多数患者 (61%) 保持精神状态稳定.
- 观察到高患病率的副作用 (94%),便秘是最常见的 (65%).
结论:
- 老年克洛扎患者面临着相当大的副作用负担,特别是便秘.
- 随着年龄的增长,可能会带来 clozapine 诱导的胃肠道低动性 (CIGH) 的未知风险.
- 迫切需要加强对老化克洛扎群体中CIGH的监测.
相关概念视频
Nonlinear Pharmacokinetics: Dependence of Elimination Half-Life and Dose Clearance
110
The elimination half-life and drug clearance of drugs following nonlinear kinetics can vary with dosage. The Michaelis-Menten parameters and drug concentration influence these factors. As the dose increases, the elimination half-life tends to lengthen, resulting in a reduction in clearance and a disproportionately larger area under the curve. The total clearance can be derived from the Michaelis-Menten equation for drugs following a one-compartment model.
A study on guinea pigs examined the...
A study on guinea pigs examined the...
110
Psychosis: Goals of Pharmacotherapy
114
Antipsychotic drugs are a crucial treatment method for acute and chronic psychoses, bipolar illness, and behavioral disorders. The selection of these drugs depends on several factors, including the state of the disease, clinical judgment, possible drug interactions, and the patient's sensitivity to adverse effects. In immediate scenarios, such as delirium and dementia, short-term treatment with low doses of high-potency typical or atypical agents can effectively manage symptom exacerbation.
114
Drug Therapy
41
The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
Antianxiety Medications
41
Analysis of Population Pharmacokinetic Data
244
Analysis of population pharmacokinetic data involves studying the behavior of drugs within diverse populations to understand their pharmacokinetic parameters. Traditional pharmacokinetic methods typically involve collecting samples from a few individuals and estimating these parameters. While these methods are commonly used, they have limitations in capturing the variability in drug response among individuals or heterogeneous populations. Population pharmacokinetics is employed to address these...
244
Factors Affecting Drug Response: Overview
1.9K
When it comes to infants and young children, they are typically administered smaller doses of medication in comparison to adults. This is primarily because their organ functions still need to fully develop, meaning their bodies are not as efficient at metabolizing or eliminating drugs. Additionally, their blood-brain barrier is more permeable than in adults. As a result, high concentrations of drugs can easily penetrate the central nervous system (CNS), potentially leading to neurological...
1.9K
Antipsychotic Drugs: Typical and Atypical Agents
164
Antipsychotic drugs are classified into first-generation (typical) drugs including phenothiazines; and second-generation (atypical) drugs. Chlorpromazine hydrochloride (Thorazine), a phenothiazine derivative, broadly impacts the central, autonomic, and endocrine systems. This drug, along with typical agents like haloperidol (Haldol), primarily works by antagonizing D2 receptors, thus reducing dopaminergic neurotransmission. However, typical antipsychotics can cause side effects such as sedation...
164


