对于患有慢性阻塞性肺病的成年人,EQ-5D基础的实用值:系统性审查,元分析和元回归
Natasha Salant1, Syed Mohiuddin2, Yuanyuan Zhang2
1Health Economics Research Centre, University of Oxford, Oxford, UK.
COPD
|July 31, 2024
概括
最近的研究表明,慢性阻塞性肺病 (COPD) 患者的健康效用值有所改善. 然而,显著的异质性需要在经济模型中仔细使用这些值.
科学领域:
- 卫生经济学 卫生经济学
- 肺部病理学 肺部病理学
- 生活质量研究 研究 生命质量研究
背景情况:
- 慢性阻塞性肺病 (COPD) 显著影响与健康相关的生活质量 (QoL).
- 实用值对于卫生经济评估和政策决策中的成本效益模型至关重要.
- 之前的元分析,如莫耶里等人. (2016年) 确定了COPD的基线实用值.
研究的目的:
- 调查近期 (2015-2024) 文献中COPD平均效用值的变化.
- 探索各种临床和研究特征的实用值的异质性.
- 更新和完善用于COPD经济建模的实用性估计.
主要方法:
- 从2015年7月到2024年5月,在MEDLINE和Embase进行了系统的文献搜索.
- 对EQ-5D实用值进行了随机效应元分析,解决了研究间的异质性.
- 使用子组分析和元回归来确定效用值的调节者.
主要成果:
- 从最近的43项研究中汇总的平均效用值为0.761 (95% CI:0.726-0.795),比之前报告的0.673增加.
- 观察到显著的异质性,表明应该谨慎使用通用效用值.
- 诱导方法,疾病阶段和区域被确定为实用值的显著调节者.
结论:
- 更新的COPD的分析实用值显示改善,可能是由于护理的进步.
- 显著的异质性强调了在成本效益分析中使用特定上下文的实用数据的重要性.
- 这些发现支持使用反映特定患者群体和研究背景的元分析实用程序,突出显示EQ-5D-5L比EQ-5D-3L更精确.
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