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Updated: Jun 18, 2025

Simultaneous Quantification of Selected Kynurenines Analyzed by Liquid Chromatography-Mass Spectrometry in Medium Collected from Cancer Cell Cultures
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Published on: May 9, 2020

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在kynurenine 3-monooxygenase中模拟难以捉摸的构造激活

Yılmaz Özkılıç1, Matthias Stein1

  • 1Molecular Simulations and Design Group, Max Planck Institute for Dynamics of Complex Technical Systems, Sandtorstrasse 1, 39106 Magdeburg, Germany. ozkilic@mpi-magdeburg.mpg.de.

Organic & biomolecular chemistry
|July 31, 2024
PubMed
概括

使用分子动力学模拟,探索了Kynurenine 3-monooxygenase (KMO) 酶活性. 研究人员阐明了KMO难以捉摸的活跃"外"状态,揭示了关键的形状变化和对FAD减少的影响.

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