在长寿人群中,肠道真菌生物体的特征
Lixia Pu1, Shifu Pang2, Wenjie Mu1
1State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu, China.
iScience
|July 31, 2024
概括
长寿的个体表现出独特的肠道真菌 (mycobiome) 签名,与老年人不同. 这项研究揭示了衰老.
科学领域:
- 老年学是一门学科.
- 微生物学 微生物学
- 菌类学 菌类学是指菌类学.
背景情况:
- 肠道微生物群在衰老中的作用已被研究,但长寿个体的肠道真菌 (mycobiome) 在很大程度上尚未被探索.
- 了解百岁老人的肠道菌群可以提供对健康衰老的见解.
- 衰老显著影响肠道微生物群,但真菌社区的动态尚不清楚.
研究的目的:
- 在一个包括百岁老人在内的队列中描述肠道菌群的签名.
- 为了识别与长寿和衰老相关的真菌模式.
- 探索不同年龄段的肠道真菌和细菌之间的关系.
主要方法:
- 从中国广西招募了251名社区居住的参与者 (24-108岁).
- 分析了不同年龄组的肠道菌群组成.
- 利用肠型分析来分类真菌和细菌群落.
主要成果:
- 肠道真菌生物组的组成随着年龄的增长而显著变化,老化被认为是主要的驱动因素.
- 长寿的个体表现出丰富的Candida肠型,并保持了像Penicillium和Aspergillus这样的核心种群.
- 长寿个体的Candida肠型与细菌体肠型有关,这种肠型在年轻人和百岁以上的人群中很常见.
结论:
- 在整个衰老过程中,肠道菌群的组成会发生变化.
- 长寿的个体具有独特的肠道真菌特征,可能与有益的酵母有关.
- 这些发现凸显了真菌生物组在健康衰老和长寿中的作用.
相关概念视频
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