来自巴西的土著人的SARS-CoV-2血清转化史 - 暴露,接种疫苗和结核病之间的相互作用
Alice Nagai1, Renan Barbosa Lemes2, José Geraldo Mill3
1Laboratory of Pathogen Manipulation, Brazilian Biosciences National Laboratory (LNBio), Department of Virology, CNPEM (Brazilian Center for Research in Energy and Materials), Campinas, Brazil.
一项针对巴西土著人口的研究发现,56%的血清转化为SARS-CoV-2. 接种疫苗显著提高了抗体的产生,这表明疫苗的有效性和这些群体的COVID-19严重程度最小.
科学领域:
- 流行病学 流行病学
- 免疫学 免疫学 免疫学
- 公共卫生 公共卫生
背景情况:
- COVID-19显著影响了全球健康,但它对代表性不足的人群的影响,比如美国的土著社区,还未得到充分研究.
- 了解这些脆弱群体中SARS-CoV-2的自然史和血清流行率对于有针对性的公共卫生干预至关重要.
研究的目的:
- 评估SARS-CoV-2血清转化率和疫苗接种对两个巴西土著人口 (图皮尼基姆人和瓜拉尼-姆比亚) 的影响.
- 确定结核病 (TB) 的患病率及其与相同人群中SARS-CoV-2血清转换的关联.
主要方法:
- 从2020年9月到2021年7月,对624人进行了回顾性血清学调查.
- 评估了SARS-CoV-2 S和N抗原血清转换,使用了三个商业ELISA套件.
- 在529个人同时评估结核病患病率.
主要成果:
- 56.0%的人表现出SARS-CoV-2血清转化.
- 接种疫苗 (Coronavac) 增加了抗S IgG的产生,从3.9%增加到48.6%.
- 结核病的患病率为11.0%,与SARS-CoV-2血清转化没有显著关联.
结论:
- 在土著人口中,Coronavac疫苗似乎是有效的,类似于巴西一般人口.
- 观察到COVID-19的严重程度最低,这表明疫苗接种之外的因素可能会提供保护.
- 高结核病发病率值得关注,尽管它没有影响SARS-CoV-2血清转化率.
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