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偏磁边缘病变作为生物标志物,用于区分多发性硬化和大脑小血管疾病

Zhibao Zhu^1,2,3,4, Yuanyuan Zhang^2,3,4, Chun Li^2,3,4

¹Department of Neurology, Fujian Medical University Union Hospital, Fuzhou, Fujian, China.

Frontiers in neurology

|July 31, 2024

概括

偏磁边缘病变 (PRL) 在超过一半的多发性硬化症 (MS) 患者中存在,但在脑小血管疾病 (CSVD) 中不存在. 这种成像标记有助于区分MS和CSVD.

科学领域:

神经学神经学
放射学放射学是一门学科.
神经成像是一种神经成像.

背景情况:

多发性硬化症 (MS) 和大脑小血管疾病 (CSVD) 在MRI上有图像相似之处,有可能误诊.
区分MS和CSVD对于及时有效治疗至关重要.

研究的目的:

确定偏磁边缘病变 (PRL) 是否可以作为神经成像标记物来区分MS和CSVD.
评估PRL在区分这两个神经疾病的诊断价值.

主要方法:

从49名MS和104名CSVD患者的3.0TMRI扫描进行了回顾性分析.
对特定的MRI特征进行视觉评估,包括PRL,缺口,CMB,EPVS,WMH和CVS.
在MS和CSVD队列中量化PRL分布和数量.

主要成果:

在78.38%的MS患者中检测到PRL,在CSVD患者中完全缺席 (0%).
在区分MS和CSVD方面,PRL的诊断准确度很高,灵敏度为78.38%,特异性为100% (AUC:0.96).

结论:

偏磁边缘病变是MS的独特成像特征,在CSVD中没有观察到.
对于MS和CSVD的临床分化和管理来说,PRL的存在或不存在非常有价值.

关键词:

生物标志物生物标志物大脑小血管疾病是大脑小血管疾病.磁共振成像技术的使用多发性硬化症多发性硬化症偏磁边缘损伤的病变

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