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在糖尿病视网膜病变中,异常神经血管合使用动脉旋转标记 (ASL) 和功能磁共振成像 (fMRI) 方法
Yu-Lin Zhong1, Rui-Yang Hu2, Xin Huang1
1Department of Ophthalmology, Jiangxi Provincial People's Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, Jiangxi, 330006, People's Republic of China.
概括
糖尿病视网膜病变 (DR) 患者表现出大脑血液流动和连接的改变,特别是在视觉和运动区域. 这种神经血管脱可能表明与DR相关的脑部变化.
科学领域:
- 神经科学是一个神经科学.
- 放射学 放射学是一门学科.
- 眼科医生 眼科 眼科
背景情况:
- 糖尿病视网膜病变 (DR) 与大脑的结构和功能变化有关.
- 对于DR对神经血管合的影响尚不清楚.
研究的目的:
- 为了研究糖尿病视网膜病变 (DR) 患者的神经血管合异常.
- 为了比较大脑血流 (CBF) 和功能连接强度 (FCS) 在DR患者和健康对照 (HC) 之间的合.
主要方法:
- 使用了休息状态功能磁共振成像 (rs-fMRI) 和动脉自旋标记成像 (ASL).
- 在灰色物质中分析了CBF-FCS合和CBF/FCS比率.
- 一个支持向量机器 (SVM) 分类了DR患者和HC.
主要成果:
- 与HC相比,DR患者的CBF-FCS合减少.
- 在DR患者的初级视觉皮层中发现CBF/FCS比率升高.
- 在前运动和补充运动区域观察到降低的CBF/FCS比率.
结论:
- 改变的CBF/FCS比率表明潜在的灰色物质体积减少或减少了DR的区域CBF.
- 视觉皮层和运动皮层的神经血管脱可能是DR神经病理学的关键机制.
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