单次低剂量甲托雷克萨特和维生素B12缺乏引起的泛细胞衰竭导致死亡:一个案例报告
Ghida Akhdar1, Inemesit Akpan1, Amanda Myles2
1Internal Medicine, Piedmont Athens Regional Medical Center, Athens, USA.
Cureus
|July 31, 2024
概括
甲托雷克萨特 (MTX) 即使在低剂量中也可能导致严重的胰岛素减肥,特别是在患有慢性脏病和维生素B12缺乏症的老年人中. 这一案例凸显了对MTX毒性进行仔细监测和管理的关键需求.
科学领域:
- 类风湿病学 类风湿病学
- 药理学 药理学是指药理学的学科.
- 内部医学 内部医学
背景情况:
- 甲甲酸 (MTX) 是一种广泛使用的疾病修饰性抗风湿药物 (DMARD),用于各种自身免疫性疾病.
- 低累积剂量的MTX通常被认为是安全的.
- 慢性病 (CKD) 和维生素B12缺乏症等并发症可以影响药物代谢和毒性.
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